Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

More than one-third of the worldwide population is overweight or obese and therefore at risk
of developing type 2 diabetes mellitus. In order to mitigate this pandemic, safer and more …

Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity,
insulin resistance, hypertension, and dyslipidemia. Although there has been significant …

Leptin and ghrelin are two hormones that have been recognized to have a major influence
on energy balance. Leptin is a mediator of long‐term regulation of energy balance …

Food intake and energy expenditure are controlled by complex, redundant, and distributed
neural systems that reflect the fundamental biological importance of adequate nutrient …

Obesity, which has developed into a global epidemic, is a risk factor in most chronic
diseases and some forms of malignancy. The discovery of leptin in 1994 has opened a new …

Leptin resistance in diet-induced obese (DIO) mice is characterized by elevated serum leptin
and a decreased response to exogenous leptin and is caused by unknown defects in the …

Leptin regulates energy homeostasis and reproductive, neuroendocrine, immune, and
metabolic functions. In this review, we describe the role of leptin in human physiology and …

The increasing incidence of obesity in developed nations is an ever-growing challenge to
health care, promoting diabetes and other diseases. The hormone leptin, which is derived …

Hypothalamic systems which regulate appetite may be permanently modified during early
development. We have previously reported hyperphagia and increased adiposity in the …