Comparative transcriptomics in human and mouse
Cross-species comparisons of genomes, transcriptomes and gene regulation are now
feasible at unprecedented resolution and throughput, enabling the comparison of human …
feasible at unprecedented resolution and throughput, enabling the comparison of human …
Modes of gene duplication contribute differently to genetic novelty and redundancy, but show parallels across divergent angiosperms
Background Both single gene and whole genome duplications (WGD) have recurred in
angiosperm evolution. However, the evolutionary effects of different modes of gene …
angiosperm evolution. However, the evolutionary effects of different modes of gene …
Neighboring genes show correlated evolution in gene expression
AT Ghanbarian, LD Hurst - Molecular biology and evolution, 2015 - academic.oup.com
When considering the evolution of a gene's expression profile, we commonly assume that
this is unaffected by its genomic neighborhood. This is, however, in contrast to what we …
this is unaffected by its genomic neighborhood. This is, however, in contrast to what we …
Underlying functional genomics of fat deposition in adipose tissue
MR Bakhtiarizadeh, M Moradi-Shahrbabak… - Gene, 2013 - Elsevier
The objective of this study was to gain insight into the underlying mechanisms of fat
deposition. Two sheep breeds with large fat-tail (Lori–Bakhtiari) and with thin-tail (Zel) were …
deposition. Two sheep breeds with large fat-tail (Lori–Bakhtiari) and with thin-tail (Zel) were …
Enhanced transcriptome maps from multiple mouse tissues reveal evolutionary constraint in gene expression
Mice have been a long-standing model for human biology and disease. Here we
characterize, by RNA sequencing, the transcriptional profiles of a large and heterogeneous …
characterize, by RNA sequencing, the transcriptional profiles of a large and heterogeneous …
Cross-species meta-analysis of transcriptomic data in combination with supervised machine learning models identifies the common gene signature of lactation …
Lactation, a physiologically complex process, takes place in mammary gland after
parturition. The expression profile of the effective genes in lactation has not …
parturition. The expression profile of the effective genes in lactation has not …
Core promoter short tandem repeats as evolutionary switch codes for primate speciation
M Ohadi, E Valipour… - American journal of …, 2015 - Wiley Online Library
Alteration in gene expression levels underlies many of the phenotypic differences across
species. Because of their highly mutable nature, proximity to the+ 1 transcription start site …
species. Because of their highly mutable nature, proximity to the+ 1 transcription start site …
Exceptionally long 5′ UTR short tandem repeats specifically linked to primates
P Namdar-Aligoodarzi, S Mohammadparast… - Gene, 2015 - Elsevier
We have previously reported genome-scale short tandem repeats (STRs) in the core
promoter interval (ie− 120 to+ 1 to the transcription start site) of protein-coding genes that …
promoter interval (ie− 120 to+ 1 to the transcription start site) of protein-coding genes that …
Measuring gene expression divergence: the distance to keep
G Glazko, A Mushegian - Biology direct, 2010 - Springer
Background Gene expression divergence is a phenotypic trait reflecting evolution of gene
regulation and characterizing dissimilarity between species and between cells and tissues …
regulation and characterizing dissimilarity between species and between cells and tissues …
Positive selection at high temperature reduces gene transcription in the bacteriophage ϕX174
CJ Brown, L Zhao, KJ Evans, D Ally… - BMC Evolutionary …, 2010 - Springer
Background Gene regulation plays a central role in the adaptation of organisms to their
environments. There are many molecular components to gene regulation, and it is often …
environments. There are many molecular components to gene regulation, and it is often …