The vagus nerve is an indispensable body-brain connection that controls vital aspects of
autonomic physiology like breathing, heart rate, blood pressure, and gut motility, reflexes …

Vagal sensory neurons constitute the major afferent supply to the airways and lungs.
Subsets of afferents are defined by their embryological origin, molecular profile …

This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

The concept of a purinergic signaling system, using purine nucleotides and nucleosides as
extracellular messengers, was first proposed over 30 years ago. After a brief introduction …

Mammalian lungs have the ability to recognize external environments by sensing different
compounds in inhaled air. Pulmonary neuroendocrine cells (PNECs) are rare, multi …

Significant progress in understanding the pharmacological characteristics and physiological
importance of homomeric and heteromeric P2X channels has been achieved in recent …

Known as the gas exchange organ, the lung is also critical for responding to the aerosol
environment in part through interaction with the nervous system. The diversity and specificity …

Pulmonary neuroendocrine cells (PNECs) have been around for 60 years in the scientific
literature, although phylogenetically they are ancient. Their traditionally ascribed functions …

Following hints in the early literature about adenosine 5′-triphosphate (ATP) injections
producing pain, an ion-channel nucleotide receptor was cloned in 1995, P2X3 subtype …

Evidence for a significant role and impact of purinergic signaling in normal and diseased
airways is now beyond dispute. The present review intends to provide the current state of …