MMP‐9 in translation: from molecule to brain physiology, pathology, and therapy

B Vafadari, A Salamian… - Journal of …, 2016 - Wiley Online Library
Abstract Matrix metalloproteinase‐9 (MMP‐9) is a member of the metzincin family of mostly
extracellularly operating proteases. Despite the fact that all of these enzymes might be target …

Matrix metalloproteinase 9 in epilepsy: the role of neuroinflammation in seizure development

E Bronisz… - Mediators of inflammation, 2016 - Wiley Online Library
Matrix metalloproteinase 9 is a proteolytic enzyme which is recently one of the more often
studied biomarkers. Its possible use as a biomarker of neuronal damage in stroke, heart …

Activation of the 5-HT7 receptor and MMP-9 signaling module in the hippocampal CA1 region is necessary for the development of depressive-like behavior

M Bijata, E Bączyńska, FE Müller, K Bijata, J Masternak… - Cell Reports, 2022 - cell.com
Major depressive disorder is a complex disease resulting from aberrant synaptic plasticity
that may be caused by abnormal serotonergic signaling. Using a combination of behavioral …

Serotonin 5‐HT 7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons

L Speranza, J Labus, F Volpicelli… - Journal of …, 2017 - Wiley Online Library
Precise control of dendritic spine density and synapse formation is critical for normal and
pathological brain functions. Therefore, signaling pathways influencing dendrite outgrowth …

Quantification of dendritic spines remodeling under physiological stimuli and in pathological conditions

E Bączyńska, KK Pels, S Basu, J Włodarczyk… - International Journal of …, 2021 - mdpi.com
Numerous brain diseases are associated with abnormalities in morphology and density of
dendritic spines, small membranous protrusions whose structural geometry correlates with …

The many roles of dystroglycan in nervous system development and function: Dystroglycan and neural circuit development

JN Jahncke, KM Wright - Developmental Dynamics, 2023 - Wiley Online Library
The glycoprotein dystroglycan was first identified in muscle, where it functions as part of the
dystrophin glycoprotein complex to connect the extracellular matrix to the actin cytoskeleton …

Serotonin 5-HT4 receptor boosts functional maturation of dendritic spines via RhoA-dependent control of F-actin

Y Schill, M Bijata, O Kopach, V Cherkas… - Communications …, 2020 - nature.com
Activity-dependent remodeling of excitatory connections underpins memory formation in the
brain. Serotonin receptors are known to contribute to such remodeling, yet the underlying …

Control of astrocyte morphology by Rho GTPases

A Zeug, FE Müller, S Anders, MK Herde, D Minge… - Brain research …, 2018 - Elsevier
Astrocytes modulate and support neuronal and synapse function via numerous mechanisms
that often rely on diffusion of signalling molecules, ions or metabolites through extracellular …

MMP-9 signaling pathways that engage rho GTPases in brain plasticity

I Figiel, PK Kruk, M Zaręba-Kozioł, P Rybak, M Bijata… - Cells, 2021 - mdpi.com
The extracellular matrix (ECM) has been identified as a critical factor affecting synaptic
function. It forms a functional scaffold that provides both the structural support and the …

[HTML][HTML] Recent advances in branching mechanisms underlying neuronal morphogenesis

S Menon, S Gupton - F1000Research, 2018 - ncbi.nlm.nih.gov
Proper neuronal wiring is central to all bodily functions, sensory perception, cognition,
memory, and learning. Establishment of a functional neuronal circuit is a highly regulated …