Insulin-lowering agents in the management of polycystic ovary syndrome

V De Leo, A La Marca, F Petraglia - Endocrine reviews, 2003 - academic.oup.com
Polycystic ovary syndrome (PCOS) is a medical condition that has brought multiple
specialists together. Gynecologists, endocrinologists, cardiologists, pediatricians, and …

Sex steroids and insulin resistance

C Livingstone, M Collison - Clinical Science, 2002 - portlandpress.com
There is extensive experimental evidence that sex steroids and insulin interact in their
actions on tissues. At physiological levels, testosterone and oestradiol are thought to be …

[HTML][HTML] Molecular progress in infertility: polycystic ovary syndrome

RS Legro, JF Strauss III - Fertility and sterility, 2002 - Elsevier
Objective: To review the evidence that polycystic ovary syndrome is a genetic disease.
Design: Review of published literature. Results: The existing literature provides a strong …

Genetics of polycystic ovary syndrome: searching for the way out of the labyrinth

E Diamanti-Kandarakis, C Piperi - Human Reproduction Update, 2005 - academic.oup.com
Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disorder presenting a
challenge for clinical investigators. It is the most common endocrine disorder of women in …

[PDF][PDF] Polycystic ovary syndrome: the influence of environmental and genetic factors

E Diamanti-Kandarakis, C Piperi… - HORMONES …, 2006 - academia.edu
Polycystic ovary syndrome (PCOS) is a complex and heterogeneous disorder characterized
by hyperandrogenemia, hyperinsulinemia, insulin resistance, and chronic anovulation. It is …

The genetics of polycystic ovary syndrome

P Amato, JL Simpson - Best practice & research Clinical obstetrics & …, 2004 - Elsevier
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder. There is evidence for a
genetic component in PCOS based on familial clustering of cases. The majority of the …

Polycystic ovary syndrome in adolescence

SK Blank, KD Helm, CR McCartney… - Annals of the New …, 2008 - Wiley Online Library
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy among reproductive‐
aged women and is characterized by hyperandrogenemia, menstrual dysfunction, and …

Polycystic ovary syndrome, insulin resistance, and molecular defects of insulin signaling

R Azziz - The Journal of Clinical Endocrinology & Metabolism, 2002 - academic.oup.com
The polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders,
affecting 4–6% of unselected women of reproductive age. More recently, it has been …

[HTML][HTML] Insulin resistance directly contributes to androgenic potential within ovarian theca cells

JW Qu, Y Wang, X Wu, L Gao, L Hou, R Erkkola - Fertility and sterility, 2009 - Elsevier
OBJECTIVE: To investigate whether insulin resistance (IR) within theca cells may directly
contribute to their hyperandrogenism, a heritable trait of polycystic ovary syndrome (PCOS) …

Association of GWAS identified INSR variants (rs2059807 & rs1799817) with polycystic ovarian syndrome in Indian women

J Dakshinamoorthy, PR Jain, T Ramamoorthy… - International journal of …, 2020 - Elsevier
Polycystic ovary syndrome (PCOS), a gynaecological endocrine disorder affects 9% of
Indian women and is linked to type II diabetes. The association of INSR (INSulin Receptor …