One of the most fascinating questions in regenerative biology is why some animals can
regenerate injured structures while others cannot. Skeletal muscle has a remarkable …

All multicellular organisms rely on intercellular communication networks to coordinate
physiological functions. As members of a dynamic social network, each cell receives …

Dedicated stem cells ensure postnatal growth, repair and homeostasis of skeletal muscle.
Following injury, muscle stem cells (MuSCs) exit from quiescence and divide to reconstitute …

Although heterogeneity is recognized within the murine satellite cell pool, a comprehensive
understanding of distinct subpopulations and their functional relevance in human satellite …

Skeletal muscle possesses a remarkable capacity to regenerate when injured, but when
confronted with major traumatic injury resulting in volumetric muscle loss (VML), the …

Volumetric muscle loss (VML) resulting from extremity trauma presents chronic and
persistent functional deficits which ultimately manifest disability. Acellular biological …

Volumetric muscle loss (VML) overwhelms the innate regenerative capacity of mammalian
skeletal muscle (SkM), leading to numerous disabilities and reduced quality of life. Immune …

Muscle regeneration depends on a robust albeit transient inflammatory response. Persistent
inflammation is a feature of age-related regenerative deficits, yet the underlying mechanisms …

During aging, there is a progressive loss of volume and function in skeletal muscle that
impacts mobility and quality of life. The repair of skeletal muscle is regulated by tissue …

Platelet-derived growth factors (PDGFs) regulate embryonic development, tissue
regeneration, and wound healing through their binding to PDGF receptors, PDGFRα and …