We performed this systematic review to assess the analgesic efficacy of perioperative
pregabalin. Subgroup analyses and meta-regression were performed to assess the impact …

Results: Caffeine plays an important role in pain modulation through their action on
adenosine receptors which are involved in nociception. The use of caffeine as adjuvant …

The efficacy of pregabalin in acute postsurgical pain has been demonstrated in numerous
studies; however, the analgesic efficacy and adverse effects of using pregabalin in various …

Pregabalin has demonstrated anti-hyperalgesic properties and was introduced into acute
pain treatment in 2001. Our aim was to evaluate the beneficial and harmful effects of …

Background Pregabalin (PGB) and gabapentin (GBP) are current and emerging drugs in the
field of pre-emptive preoperative analgesia. However, the role of PGB or GBP in acute …

Postsurgical pain is normally perceived as nociceptive pain. Surgical trauma has been
known to induce central and peripheral sensitization and hyperalgesia, which in untreated …

BACKGROUND: Nonopioid adjuvant medications are increasingly included among
perioperative Enhanced Recovery After Surgery protocols. Preoperative pregabalin has …

Background: Postoperative pain is one of the most important complications encountered
after surgery. A number of options are available for treating pain following surgery. One of …

Analgesic drugs in a combination-form can achieve greater efficacy with lesser side effects
compared to either drug alone. The combination of drugs acting at different targets or …

Study objective To determine whether single preoperative administration of 2 different doses
of pregabalin (75 and 150 mg) could decrease postoperative pain intensity and opioid …