Mounting evidence suggests that neuroinflammation is not just a consequence but a vital
contributor to the development and progression of Parkinson's disease (PD). Microglia in …

Neurotransmitters are considered as a fundamental regulator in the process of neuronal
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …

Parkinson's disease (PD) is a heterogeneous neurodegenerative disease involving multiple
etiologies and pathogenesis, in which neuroinflammation is a common factor. Both …

Parkinson's disease (PD) is a chronic, progressive and disabling neurodegenerative
disorder. The prevalence of PD has risen considerably over the past decades. A growing …

Chronic neuroinflammation is of great importance in the pathogenesis of Parkinson's
disease (PD). During the process of neuroinflammation, overactivated microglia release …

Histamine is a major peripheral inflammatory mediator and a neurotransmitter in the central
nervous system. We have reported that histamine induces microglia activation and releases …

Rotenone is one of the most widely used insecticide and pisicides in the US and around the
world. Epidemiological evidences suggest that rotenone exposure may be a risk factor for …

Different dopaminergic (DA) neuronal subgroups exhibit distinct vulnerability to stress, while
the underlying mechanisms are elusive. Here we report that the transient receptor potential …

The histamine H4 receptor, belonging to the family of G-protein coupled receptors, is an
increasingly attractive drug target. It plays an indispensable role in many cellular pathways …