Pharmacological targeting of microglial activation: new therapeutic approach
CY Liu, X Wang, C Liu, HL Zhang - Frontiers in Cellular Neuroscience, 2019 - frontiersin.org
Mounting evidence suggests that neuroinflammation is not just a consequence but a vital
contributor to the development and progression of Parkinson's disease (PD). Microglia in …
contributor to the development and progression of Parkinson's disease (PD). Microglia in …
Restoration and targeting of aberrant neurotransmitters in Parkinson's disease therapeutics
D Yadav, P Kumar - Neurochemistry international, 2022 - Elsevier
Neurotransmitters are considered as a fundamental regulator in the process of neuronal
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …
growth, differentiation and survival. Parkinson's Disease (PD) occurs due to extensive …
G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders
Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …
Identifying treatment targets is challenging because the diseases are resulting from …
Neuroinflammation in Parkinson's disease: triggers, mechanisms, and immunotherapies
T Wang, C Shi, H Luo, H Zheng, L Fan… - The …, 2022 - journals.sagepub.com
Parkinson's disease (PD) is a heterogeneous neurodegenerative disease involving multiple
etiologies and pathogenesis, in which neuroinflammation is a common factor. Both …
etiologies and pathogenesis, in which neuroinflammation is a common factor. Both …
Towards improved screening of toxins for Parkinson's risk
Parkinson's disease (PD) is a chronic, progressive and disabling neurodegenerative
disorder. The prevalence of PD has risen considerably over the past decades. A growing …
disorder. The prevalence of PD has risen considerably over the past decades. A growing …
Src inhibition attenuates neuroinflammation and protects dopaminergic neurons in Parkinson's disease models
H Yang, L Wang, C Zang, Y Wang, J Shang… - Frontiers in …, 2020 - frontiersin.org
Chronic neuroinflammation is of great importance in the pathogenesis of Parkinson's
disease (PD). During the process of neuroinflammation, overactivated microglia release …
disease (PD). During the process of neuroinflammation, overactivated microglia release …
Histamine Induces Microglia Activation and the Release of Proinflammatory Mediators in Rat Brain Via H1R or H4R
W Zhang, X Zhang, Y Zhang, C Qu, X Zhou… - Journal of Neuroimmune …, 2020 - Springer
Histamine is a major peripheral inflammatory mediator and a neurotransmitter in the central
nervous system. We have reported that histamine induces microglia activation and releases …
nervous system. We have reported that histamine induces microglia activation and releases …
Rotenone neurotoxicity: Relevance to Parkinson's disease
Rotenone is one of the most widely used insecticide and pisicides in the US and around the
world. Epidemiological evidences suggest that rotenone exposure may be a risk factor for …
world. Epidemiological evidences suggest that rotenone exposure may be a risk factor for …
[HTML][HTML] TRPM2 as a conserved gatekeeper determines the vulnerability of DA neurons by mediating ROS sensing and calcium dyshomeostasis
P Ye, Q Fang, X Hu, W Zou, M Huang, M Ke, Y Li… - Progress in …, 2023 - Elsevier
Different dopaminergic (DA) neuronal subgroups exhibit distinct vulnerability to stress, while
the underlying mechanisms are elusive. Here we report that the transient receptor potential …
the underlying mechanisms are elusive. Here we report that the transient receptor potential …
Enigmatic Histamine Receptor H4 for Potential Treatment of Multiple Inflammatory, Autoimmune, and Related Diseases
P Mehta, P Miszta, P Rzodkiewicz, O Michalak… - Life, 2020 - mdpi.com
The histamine H4 receptor, belonging to the family of G-protein coupled receptors, is an
increasingly attractive drug target. It plays an indispensable role in many cellular pathways …
increasingly attractive drug target. It plays an indispensable role in many cellular pathways …