Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes

C Souilhol, J Serbanovic-Canic, M Fragiadaki… - Nature Reviews …, 2020 - nature.com
Flowing blood generates a frictional force called shear stress that has major effects on
vascular function. Branches and bends of arteries are exposed to complex blood flow …

Targeting the microenvironment of vulnerable atherosclerotic plaques: an emerging diagnosis and therapy strategy for atherosclerosis

S Zhang, Y Liu, Y Cao, S Zhang, J Sun… - Advanced …, 2022 - Wiley Online Library
Atherosclerosis is considered one of the primary causes of cardiovascular diseases (CVDs).
Unpredictable rupture of the vulnerable atherosclerotic plaques triggers adverse …

[HTML][HTML] Plaque angiogenesis and intraplaque hemorrhage in atherosclerosis

L Parma, F Baganha, PHA Quax… - European journal of …, 2017 - Elsevier
Acute cardiovascular events, due to rupture or erosion of an atherosclerotic plaque,
represent the major cause of morbidity and mortality in patients. Growing evidence suggests …

Endothelial barrier function and leukocyte transmigration in atherosclerosis

TJ Sluiter, JD van Buul, S Huveneers, PHA Quax… - Biomedicines, 2021 - mdpi.com
The vascular endothelium is a highly specialized barrier that controls passage of fluids and
migration of cells from the lumen into the vessel wall. Endothelial cells assist leukocytes to …

Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics

S Xu, D Kamato, PJ Little, S Nakagawa… - Pharmacology & …, 2019 - Elsevier
Atherosclerosis, the principal cause of cardiovascular death worldwide, is a pathological
disease characterized by fibro-proliferation, chronic inflammation, lipid accumulation, and …

Roles of growth differentiation factor 15 in atherosclerosis and coronary artery disease

J Wang, L Wei, X Yang, J Zhong - Journal of the American Heart …, 2019 - Am Heart Assoc
The majority of acute cardiovascular events (CVE) in patients are caused by occlusive
thrombosis because of rupture or erosion of atherosclerotic plaques. 1 Growth differentiation …

Inflammation in vein graft disease

MR De Vries, PHA Quax - Frontiers in cardiovascular medicine, 2018 - frontiersin.org
Bypass surgery is one of the most frequently used strategies to revascularize tissues
downstream occlusive atherosclerotic lesions. For venous bypass surgery the great …

Progress in Stimuli‐Responsive Biomaterials for Treating Cardiovascular and Cerebrovascular Diseases

C Tapeinos, H Gao, T Bauleth‐Ramos, HA Santos - Small, 2022 - Wiley Online Library
Cardiovascular and cerebrovascular diseases (CCVDs) describe abnormal vascular system
conditions affecting the brain and heart. Among these, ischemic heart disease and ischemic …

T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword

KH Simons, A de Jong, JW Jukema… - Nature Reviews …, 2019 - nature.com
The role of inflammation in cardiovascular disease (CVD) is now widely accepted. Immune
cells, including T cells, are influenced by inflammatory signals and contribute to the onset …

Ultrastructural pathology of atherosclerosis, calcific aortic valve disease, and bioprosthetic heart valve degeneration: commonalities and differences

A Kostyunin, R Mukhamadiyarov, T Glushkova… - International Journal of …, 2020 - mdpi.com
Atherosclerosis, calcific aortic valve disease (CAVD), and bioprosthetic heart valve
degeneration (alternatively termed structural valve deterioration, SVD) represent three …