Glia plays a crucial role in the maintenance of neuronal homeostasis in the central nervous
system. The microglial production of immune factors is believed to play an important role in …

Peripheral nerve injury (PNI) is a complex disease that often appears in young adults. It is
characterized by a high incidence, limited treatment options, and poor clinical outcomes …

Mesenchymal stem cells (MSCs) represent a promising therapeutic approach in nerve tissue
engineering. To date, the local implantation of MSC in injured nerves has been the only …

Abstract Treatment of neuropathic pain is a clinical challenge likely because of the time-
dependent changes in many neurotransmitter systems, growth factors, ionic channels …

The use of autografted nerve in surgical repair of peripheral nerve injuries (PNI) is severely
limited due to donor site morbidity and restricted tissue availability. As an alternative …

Although peripheral nerve system has intrinsic regeneration potential, recovery from
peripheral nerve injury (PNI) is often far from optimal, leading to partial or complete loss of …

Unlike central nervous system neurons; those in the peripheral nervous system have the
potential for full regeneration after injury. Following injury, recovery is controlled by schwann …

Neuroma formation after peripheral nerve transection often leads to severe neuropathic
pain. Regenerative peripheral nerve interface has been shown to reduce painful neuroma in …

Peripheral nerve injuries impose significant health and economic consequences, yet no
surgical repair can deliver a complete recovery of sensory or motor function. Traditional …

Small-fiber neuropathy (SFN) is a disorder of peripheral nerves commonly found in patients
with diabetes mellitus, HIV infection, and those receiving chemotherapy. The complexity of …