Structural modification aimed for improving solubility of lead compounds in early phase drug discovery
Many lead compounds fail to reach clinical trials despite being potent because of low
bioavailability attributed to their insufficient solubility making solubility a primary and crucial …
bioavailability attributed to their insufficient solubility making solubility a primary and crucial …
Recent advances in the synthesis of hydantoins: the state of the art of a valuable scaffold
L Konnert, F Lamaty, J Martinez, E Colacino - Chemical Reviews, 2017 - ACS Publications
The review highlights the hydantoin syntheses presented from the point of view of the
preparation methods. Novel synthetic routes to various hydantoin structures, the advances …
preparation methods. Novel synthetic routes to various hydantoin structures, the advances …
Protein structure prediction with in-cell photo-crosslinking mass spectrometry and deep learning
While AlphaFold2 can predict accurate protein structures from the primary sequence,
challenges remain for proteins that undergo conformational changes or for which few …
challenges remain for proteins that undergo conformational changes or for which few …
Synthesis and antimicrobial activity of some new thiazole, thiophene and pyrazole derivatives containing benzothiazole moiety
S Bondock, W Fadaly, MA Metwally - European journal of medicinal …, 2010 - Elsevier
In an attempt to find a new class of antimicrobial agents, a series of thiazole, thiophene,
pyrazole and other related products containing benzothiazole moiety were prepared via the …
pyrazole and other related products containing benzothiazole moiety were prepared via the …
The importance of plasma protein binding in drug discovery
GL Trainor - Expert opinion on drug discovery, 2007 - Taylor & Francis
Plasma protein binding of drugs is a well-recognised phenomena, but it is only recently that
the implications for drug action in vivo have been fully appreciated. Plasma proteins, by …
the implications for drug action in vivo have been fully appreciated. Plasma proteins, by …
Hit discovery and hit-to-lead approaches
GM Keserű, GM Makara - Drug discovery today, 2006 - Elsevier
Hit discovery technologies range from traditional high-throughput screening to affinity
selection of large libraries, fragment-based techniques and computer-aided de novo design …
selection of large libraries, fragment-based techniques and computer-aided de novo design …
Cyclin dependent kinase 9 inhibitors for cancer therapy: miniperspective
YA Sonawane, MA Taylor, JV Napoleon… - Journal of medicinal …, 2016 - ACS Publications
Cyclin dependent kinase (CDK) inhibitors have been the topic of intense research for nearly
2 decades due to their widely varied and critical functions within the cell. Recently CDK9 has …
2 decades due to their widely varied and critical functions within the cell. Recently CDK9 has …
Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors
I Collins, MD Garrett - Current opinion in pharmacology, 2005 - Elsevier
The cyclin-dependent kinase (CDK) family of serine/threonine kinases regulate progression
through each stage of the cell division cycle and as such are major targets for deregulation …
through each stage of the cell division cycle and as such are major targets for deregulation …
4-Arylazo-3,5-diamino-1H-pyrazole CDK Inhibitors: SAR Study, Crystal Structure in Complex with CDK2, Selectivity, and Cellular Effects
V Kryštof, P Cankař, I Fryšová, J Slouka… - Journal of medicinal …, 2006 - ACS Publications
In a routine screening of our small-molecule compound collection we recently identified 4-
arylazo-3, 5-diamino-1 H-pyrazoles as a novel group of ATP antagonists with moderate …
arylazo-3, 5-diamino-1 H-pyrazoles as a novel group of ATP antagonists with moderate …
Mechanistic selectivity investigation and 2D-QSAR study of some new antiproliferative pyrazoles and pyrazolopyridines as potential CDK2 inhibitors
Novel series of diphenyl-1H-pyrazoles (4a-g) and pyrazolo [3, 4-b] pyridines (5a-g and 7a-i)
were synthesized and evaluated for their antiproliferative activity against breast cancer cell …
were synthesized and evaluated for their antiproliferative activity against breast cancer cell …