The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members)
has been implicated in cancer and other human diseases. However, in contrast to the direct …

Our brain serves as a center for cognitive function and neurons within the brain relay and
store information about our surroundings and experiences. Modulation of this complex …

The development, homeostasis, and regeneration of complex organ systems require
extensive cell–cell communication to ensure that different cells proliferate, migrate …

Eph receptor tyrosine kinases and ephrins have key roles in regulation of the migration and
adhesion of cells required to form and stabilize patterns of cell organization during …

Dendritic spines are small protrusions that cover the surface of dendrites and bear the
postsynaptic component of excitatory synapses. Having an enlarged head connected to the …

Ephrins are cell-surface-tethered ligands for Eph receptors, the largest family of receptor
tyrosine kinases. During development, the Eph/ephrin cell communication system appears …

Protein subcellular localization is fundamental to the establishment of the body axis, cell
migration, synaptic plasticity, and a vast range of other biological processes. Protein …

Astrocytes contribute on both development and function of synapses, but it remains unclear
whether direct astrocytic contacts regulate development of individual synapses. Two-photon …

Crosstalk between inflammatory signalling pathways and receptor tyrosine kinases has
been revealed as an indicator of cancer malignant progression. In the present study, we …

Eph receptors and ephrin ligands are widely expressed in epithelial cells and mediate cell-
cell interaction. EphA2 is expressed in various cancer tissues and cell lines. Although the …