Acrylamide in food: Occurrence, metabolism, molecular toxicity mechanism and detoxification by phytochemicals

F Yan, L Wang, L Zhao, C Wang, Q Lu, R Liu - Food and Chemical …, 2023 - Elsevier
Acrylamide (ACR) is a common pollutant formed during food thermal processing such as
frying, baking and roasting. ACR and its metabolites can cause various negative effects on …

Protective effects of morin against acrylamide-induced hepatotoxicity and nephrotoxicity: A multi-biomarker approach

FM Kandemir, S Yıldırım, S Kucukler… - Food and chemical …, 2020 - Elsevier
Acrylamide (ACR) is a heat-induced carcinogen substance that is found in some foods due
to cooking or other thermal processes. The aim of present study was to assess the probable …

Morin protects against acrylamide-induced neurotoxicity in rats: an investigation into different signal pathways

C Gur, FM Kandemir, E Darendelioglu… - … Science and Pollution …, 2021 - Springer
The presented study investigates the effects of morin against toxicity induced by acrylamide
(ACR) in the brains of Sprague Dawley rats. In this study, neurotoxicity was induced by orally …

Molecular signaling pathways in doxorubicin-induced nephrotoxicity and potential therapeutic agents

C Lu, J Wei, C Gao, M Sun, D Dong, Z Mu - International …, 2025 - Elsevier
Doxorubicin (DOX), an anthracycline chemotherapeutic agent, is extensively utilized in the
clinical management of both solid and hematological malignancies. Nevertheless, the …

[HTML][HTML] Eriodictyol attenuates doxorubicin-induced nephropathy by activating the AMPK/Nrf2 signalling pathway

RM Badi, EF Khaleel, HH Satti, R Monir - Journal of Traditional and …, 2024 - Elsevier
Doxorubicin (DOX), an anthracycline chemotherapy, plays a prominent role in the treatment
of various cancers. Unfortunately, its nephrotoxic effects limit its dosing and expose cancer …

Acylated ghrelin protects against doxorubicin‐induced nephropathy by activating silent information regulator 1

AA Shati, AF El‐Kott - Basic & Clinical Pharmacology & …, 2021 - Wiley Online Library
This study investigated the nephroprotective role of acylated ghrelin (AG) against DOX‐
induced nephropathy and examined whether the protection involves silent information …

Ginkgo Biloba Extract Alleviates Methotrexate-Induced Renal Injury: New Impact on PI3K/Akt/mTOR Signaling and MALAT1 Expression

IO Sherif, NH Al-Shaalan, D Sabry - Biomolecules, 2019 - mdpi.com
Renal injury induced by the chemotherapeutic agent methotrexate (MTX) is a serious
adverse effect that has limited its use in the treatment of various clinical conditions. The …

The therapeutic effect of hesperetin on doxorubicin-induced testicular toxicity: Potential roles of the mechanistic target of rapamycin kinase (mTOR) and dynamin …

A Tektemur, NK Tektemur, EE Güzel - Toxicology and Applied …, 2022 - Elsevier
Clinical utilization of doxorubicin (DOX), which is a commonly used chemotherapeutic, is
restricted due to toxic effects on various tissues. Using hesperetin (HST), an antioxidant …

[HTML][HTML] Irbesartan ameliorates inflammation via transendothelial leukocyte migration due to VCAM-1/NOX-1 signaling in cisplatin-induced cardiotoxicity

DU Karatopuk, S Özkula, E Aydoğdu… - Iranian Journal of …, 2023 - ncbi.nlm.nih.gov
Objective (s): Cisplatin (CP) is frequently used in various types of cancers. The cardiotoxic
effects of this agent limit its usage. Our study seeks to investigate the protective effects of …

Autophagy modulation by irbesartan mitigates the pulmonary fibrotic alterations in bleomycin challenged rats: Comparative study with rapamycin

HA Alsayed, HMF Mohammad, CM Khalil… - Life Sciences, 2022 - Elsevier
Aims In pulmonary fibrosis, autophagy handles the maintenance of alveolar epithelial cells,
prevents epithelial-mesenchymal transition (EMT), and controls collagen turnover. The …