Healthcare disparities are a persistent societal problem. One of the contributing factors to
this status quo is the lack of diversity and representativeness of research efforts, which result …

Black men with prostate cancer have historically had worse outcomes than white men with
prostate cancer. The causes of this disparity in outcomes are multi-factorial, but a potential …

MYB acts as a potentiator of aggressiveness and castration resistance in prostate cancer
(PCa) through aberrant activation of androgen receptor (AR) signaling. Since Black men …

The androgen receptor (AR) plays an essential role in the growth and progression of
prostate cancer (CaP). Ligand-activated AR inside the nucleus binds to the androgen …

The biological actions of the vitamin D receptor (VDR) have been investigated intensively for
over 100 years and has led to the identification of significant insights into the repertoire of its …

African American (AA) prostate cancer associates with vitamin D3 deficiency, but vitamin D
receptor (VDR) genomic actions have not been investigated in this context. We undertook …

The androgen receptor (AR) is the critical driver in prostate cancer and exerts its function
mainly through transcriptional control. Recent advances in clinical studies and cell line …

Prostate cancer (PCa) is one of the most common malignancies in males worldwide, and its
development and progression involve the regulation of multiple metabolic pathways …

Prostate cancer (PCa) incidence, morbidity, and mortality rates are significantly impacted by
racial disparities. Despite innovative therapeutic approaches and advancements in …

Dihydrotestosterone (DHT) and testosterone (T), which mediate androgen receptor nuclear
translocation and target gene transcription, are crucial androgens and essential molecular …