Role of p38 MAPK signalling in testis development and male fertility

D Luo, Z He, C Yu, Q Guan - Oxidative medicine and cellular …, 2022 - Wiley Online Library
The testis is an important male reproductive organ, which ensures reproductive function via
the secretion of testosterone and the generation of spermatozoa. Testis development begins …

Molecular markers: A new paradigm in the prediction of sperm freezability

M Ďuračka, F Benko, E Tvrdá - International Journal of Molecular …, 2023 - mdpi.com
For decades now, sperm cryopreservation has been a pillar of assisted reproduction in
animals as well as humans. Nevertheless, the success of cryopreservation varies across …

Proteomic profiling of fallopian tube-derived extracellular vesicles using a microfluidic tissue-on-chip system

D Zha, S Rayamajhi, J Sipes, A Russo, HB Pathak, K Li… - Bioengineering, 2023 - mdpi.com
The human fallopian tube epithelium (hFTE) is the site of fertilization, early embryo
development, and the origin of most high-grade serous ovarian cancers (HGSOCs). Little is …

Hexachlorocyclohexane impairs human sperm motility by affecting lysine glutarylation and mitochondrial functions

L Yang, G Mei, Y Yang, J Cui, S Peng, Z Peng… - Food and Chemical …, 2023 - Elsevier
Decreased sperm motility is a leading cause of male infertility and persistent organic
pollutants are known to contribute significantly to the development of this disease. The …

Regulation of germline proteostasis by HSF1 and insulin/IGF-1 signaling

T Muhammad, J Li - Biochemical Society Transactions, 2023 - portlandpress.com
Protein homeostasis (proteostasis) is essential for cellular function and organismal health
and requires the concerted actions of protein synthesis, folding, transport, and turnover. In …

KCNQ1 potassium channel expressed in human sperm is involved in sperm motility, acrosome reaction, protein tyrosine phosphorylation, and ion homeostasis during …

T Gao, K Li, F Liang, J Yu, A Liu, Y Ni, P Sun - Frontiers in physiology, 2021 - frontiersin.org
Potassium channels are involved in membrane hyperpolarization and ion homeostasis
regulation during human sperm capacitation. However, the types of potassium channels in …

Integrated metabolomics and phosphoproteomics reveal the protective role of exosomes from human umbilical cord mesenchymal stem cells in naturally aging mouse …

M Ling, C Tang, X Yang, N Yu, Y Song, W Ding… - Experimental Cell …, 2023 - Elsevier
Background Aging is characterized by a general decline in cellular function, which ultimately
affects whole body homeostasis. This study aimed to investigate the effects and underlying …

Inhibition of p38MAPK signalling pathway alleviates radiation‐induced testicular damage through improving spermatogenesis

J Yang, X Ou, M Shu, J Wang, X Zhang… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Damage to the testis following exposure to ionizing
radiation has become an urgent problem to be solved. Here we have investigated if …

[HTML][HTML] Production of functional sperm from in vitro-cultured premeiotic spermatogonia in a marine fish

H Zhang, WW Zhang, CY Mo, MD Dong, KT Jia… - Zoological …, 2022 - ncbi.nlm.nih.gov
In vitro production of functional gametes can revolutionize reproduction by reducing
generation intervals and accelerating genetic breeding in aquaculture, especially in fish with …

Analyzing the effect of heparin on in vitro capacitation and spermatozoal RNA population in goats

B Sahoo, B Mishra, R Bhaskar, YNV Vikas… - International Journal of …, 2023 - Elsevier
Heparin is a glycosaminoglycan polymer that is commonly used as an anticoagulant.
Heparin also induces in vitro capacitation in spermatozoa, although its molecular …