One of the most important branches of genetic engineering is the expression of recombinant
proteins using biological expression systems. Nowadays, different expression systems are …

Yeasts are outstanding hosts for the production of functional recombinant proteins with
industrial or medical applications. Great attention has been emerged on yeast due to the …

Catharanthine can be coupled with vindoline to synthesize vinblastine and vincristine, which
have been used clinically as potent anticancer drugs. However, the structural complexity …

Folding and processing of proteins in the endoplasmic reticulum (ER) are major
impediments in the production and secretion of proteins from Pichia pastoris (Komagataella …

Pichia pastoris is the most frequently used yeast system for heterologous protein production
today. The last few years have seen several products based on this platform reach approval …

The methylotrophic yeast Pichia pastoris (syn. Komagataella spp.) is one of the most
important production systems for heterologous proteins. After the first genome sequences …

The heterologous expression of biosynthetic pathways for pharmaceutical or fine chemical
production requires suitable expression hosts and vectors. In eukaryotes, the pathway flux is …

Age-related cataracts are closely associated with lens chronological aging, oxidation,
calcium imbalance, hydration and crystallin modifications. Accumulating evidence indicates …

Over the past 100 years, industrial biotechnology has grown into a multibillion dollar market,
which now has even begun to include large parts of chemical, material, and fuel production …

The development of Pichia pastoris as a production platform for recombinant proteins has
been a remarkable success story over the last three decades. Stable cheap production …