MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …

▪ Abstract The first mouse microphthalmia transcription factor (Mitf) mutation was discovered
over 60 years ago, and since then over 24 spontaneous and induced mutations have been …

With several hundred genetic diseases and an advantageous genome structure, dogs are
ideal for mapping genes that cause disease. Here we report the development of a …

Perhaps the most obvious manifestation of the complex interplay between environmental
cues, signal transduction pathways, and transcription factors underlying the genesis and …

Half of all vertebrate species are teleost fish. What accounts for this explosion of
biodiversity? Recent evidence and advances in evolutionary theory suggest that genomic …

Wnt signals regulate differentiation of neural crest cells through the β‐catenin associated
with a nuclear mediator of the lymphoid‐enhancing factor 1 (LEF‐1)/T‐cell factors (TCFs) …

During vertebrate eye development, the cells of the optic vesicle (OV) become either
neuroretinal progenitors expressing the transcription factor Chx10, or retinal pigment …

Microphthalmia-associated transcription factor (MITF) regulates the differentiation and
development of melanocytes and retinal pigment epithelium and is also responsible for …

The retina pigment epithelium (RPE) is fundamental for the development and function of the
vertebrate eye. Molecularly, the presumptive RPE can be identified by the early expression …

The study of vertebrate pigment patterns is a classic and enduring field of developmental
biology. Knowledge of pigment pattern development comes from a variety of systems …