International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …
therapeutics and various drugs in development. Their diversity of structure and function …
[HTML][HTML] A brain-centric model of suicidal behavior
The suicide death toll is alarmingly high, outnumbering deaths from war and homicide
worldwide (1). Many factors contribute to suicide death, making it difficult to prevent because …
worldwide (1). Many factors contribute to suicide death, making it difficult to prevent because …
[PDF][PDF] Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems
The dorsal raphe (DR) constitutes a major serotonergic input to the forebrain and modulates
diverse functions and brain states, including mood, anxiety, and sensory and motor …
diverse functions and brain states, including mood, anxiety, and sensory and motor …
Neurotransmitter systems in the etiology of major neurological disorders: Emerging insights and therapeutic implications
Neurotransmitters serve as chemical messengers playing a crucial role in information
processing throughout the nervous system, and are essential for healthy physiological and …
processing throughout the nervous system, and are essential for healthy physiological and …
[HTML][HTML] Major depression: one brain, one disease, one set of intertwined processes
EV Filatova, MI Shadrina, PA Slominsky - Cells, 2021 - mdpi.com
Major depressive disorder (MDD) is a heterogeneous disease affecting one out of five
individuals and is the leading cause of disability worldwide. Presently, MDD is considered a …
individuals and is the leading cause of disability worldwide. Presently, MDD is considered a …
[HTML][HTML] Emotional roles of mono-aminergic neurotransmitters in major depressive disorder and anxiety disorders
Y Liu, J Zhao, W Guo - Frontiers in psychology, 2018 - frontiersin.org
A growing body of researches support a role for dysfunction of serotoninergic,
noradrenergic, and dopaminergic systems in the neurobiological processes involved in …
noradrenergic, and dopaminergic systems in the neurobiological processes involved in …
Neuroplasticity underlying the comorbidity of pain and depression
L Doan, T Manders, J Wang - Neural plasticity, 2015 - Wiley Online Library
Acute pain induces depressed mood, and chronic pain is known to cause depression.
Depression, meanwhile, can also adversely affect pain behaviors ranging from …
Depression, meanwhile, can also adversely affect pain behaviors ranging from …
[HTML][HTML] Neuroanatomical substrates of rodent social behavior: the medial prefrontal cortex and its projection patterns
J Ko - Frontiers in neural circuits, 2017 - frontiersin.org
Social behavior encompasses a number of distinctive and complex constructs that form the
core elements of human imitative culture, mainly represented as either affiliative or …
core elements of human imitative culture, mainly represented as either affiliative or …
[HTML][HTML] Optogenetic dissection of medial prefrontal cortex circuitry
The medial prefrontal cortex (mPFC) is critically involved in numerous cognitive functions,
including attention, inhibitory control, habit formation, working memory and long-term …
including attention, inhibitory control, habit formation, working memory and long-term …
The 5-HT1A receptor: signaling to behavior
PR Albert, F Vahid-Ansari - Biochimie, 2019 - Elsevier
The 5-HT1A receptor is highly expressed both in 5-HT neurons as a presynaptic inhibitory
autoreceptor, and in many brain regions innervated by 5-HT as a post-synaptic …
autoreceptor, and in many brain regions innervated by 5-HT as a post-synaptic …