Directional migration is an important component of cell motility. Although the basic
mechanisms of random cell movement are well characterized, no single model explains the …

During development, neural networks are established in a highly organized manner, which
persists throughout life. Neurotrophins play crucial roles in the developing nervous system …

Among the many signalling lipids, endocannabinoids are increasingly recognized for their
important roles in neuronal and glial development. Recent experimental evidence suggests …

Motile growth cones lead growing axons through developing tissues to synaptic targets.
These behaviors depend on the organization and dynamics of actin filaments that fill the …

Ca2+ signals have profound and varied effects on growth cone motility and guidance.
Modulation of Ca2+ influx and release from stores by guidance cues shapes Ca2+ signals …

Neuronal motility is a fundamental feature that underlies the development, regeneration, and
plasticity of the nervous system. Two major developmental events—directed migration of …

Netrins are a family of proteins that direct cell and axon migration during development.
Three secreted netrins (netrin-1,-3 and-4) have been identified in mammals, in addition to …

Graded distributions of extracellular cues guide developing axons toward their targets. A
network of second messengers—Ca2+ and cyclic nucleotides—shapes cue-derived …

Postmitotic neurons in the developing cortex migrate along radial glial fibers to their proper
location in the cortical plate and form the layered structure. Here we report that the radial …

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the
progress made in this area of signaling research has yielded findings that offer the potential …