Beyond their many well-established biological aberrations, solid tumours create an
abnormal physical microenvironment that fuels cancer progression and confers treatment …

Aberrant activation of the Wnt pathway is emerging as a frequent event during prostate
cancer that can facilitate tumor formation, progression, and therapeutic resistance. Recent …

Background: Bone is a frequent site of metastases from breast cancer, but existing
therapeutic options are not satisfactory. Although osteoblasts have active roles in cancer …

Background: Advanced breast cancer metastasizes to many organs including bone, but few
effective treatments are available. Here we report that induced tumor-suppressing (iTS) …

Prostate cancer (PCa) is an increasingly prevalent health problem in the developed world.
Effective treatment options exist for localized PCa, but metastatic PCa has fewer treatment …

The overactivation of canonical Wnt/β‐catenin pathway and the maintenance of cancer stem
cells (CSCs) are essential for the onset and malignant progression of most human cancers …

Metastatic bone disease is a complex condition resulting from the migration and colonization
of cancer cells from their primary site to the bone microenvironment, where they typically …

Osteosarcoma (OS) is the most frequent primary bone cancer, which is mainly suffered by
children and young adults. While the current surgical treatment combined with …

Simple Summary Breast cancer (BCa) is a devastating disease, which has a high
prevalence and mortality in women. BCa metastasis is a major cause of mortality, and bone …

Simple Summary This review describes how osteocytes, the most abundant cells in bone,
act in cancers that grow in bone. It summarizes how cancer cells reprogram osteocytes to …