Role of the extremolytes ectoine and hydroxyectoine as stress protectants and nutrients: genetics, phylogenomics, biochemistry, and structural analysis

L Czech, L Hermann, N Stöveken, AA Richter… - Genes, 2018 - mdpi.com
Fluctuations in environmental osmolarity are ubiquitous stress factors in many natural
habitats of microorganisms, as they inevitably trigger osmotically instigated fluxes of water …

[HTML][HTML] Stressed out: Bacterial response to high salinity using compatible solute biosynthesis and uptake systems, lessons from Vibrionaceae

GJ Gregory, EF Boyd - Computational and structural biotechnology journal, 2021 - Elsevier
Bacteria have evolved mechanisms that allow them to adapt to changes in osmolarity and
some species have adapted to live optimally in high salinity environments such as in the …

[HTML][HTML] Biosynthetic potential of the global ocean microbiome

L Paoli, HJ Ruscheweyh, CC Forneris, F Hubrich… - Nature, 2022 - nature.com
Natural microbial communities are phylogenetically and metabolically diverse. In addition to
underexplored organismal groups, this diversity encompasses a rich discovery potential for …

Biosynthesis of the stress-protectant and chemical chaperon ectoine: biochemistry of the transaminase EctB

AA Richter, CN Mais, L Czech, K Geyer… - Frontiers in …, 2019 - frontiersin.org
Bacteria frequently adapt to high osmolarity surroundings through the accumulation of
compatible solutes. Ectoine is a prominent member of these types of stress protectants and …

Osmotic adaptation and compatible solute biosynthesis of phototrophic bacteria as revealed from genome analyses

JF Imhoff, T Rahn, S Künzel, A Keller, SC Neulinger - Microorganisms, 2020 - mdpi.com
Osmotic adaptation and accumulation of compatible solutes is a key process for life at high
osmotic pressure and elevated salt concentrations. Most important solutes that can protect …

Biochemical diversity of 2-oxoglutarate-dependent oxygenases

RP Hausinger - 2015 - books.rsc.org
This chapter summarizes the diverse array of biochemical transformations that are catalysed
by Fe (ii)-and 2-oxoglutarate (2OG, also known as α-ketoglutarate)-dependent oxygenases …

High-efficiency production of 5-hydroxyectoine using metabolically engineered Corynebacterium glutamicum

L Jungmann, SL Hoffmann, C Lang, R De Agazio… - Microbial Cell …, 2022 - Springer
Background Extremolytes enable microbes to withstand even the most extreme conditions in
nature. Due to their unique protective properties, the small organic molecules, more and …

The ups and downs of ectoine: structural enzymology of a major microbial stress protectant and versatile nutrient

L Hermann, CN Mais, L Czech, SHJ Smits… - Biological …, 2020 - degruyter.com
Ectoine and its derivative 5-hydroxyectoine are compatible solutes and chemical
chaperones widely synthesized by Bacteria and some Archaea as cytoprotectants during …

Composition and predicted metabolic capacity of upper and lower airway microbiota of healthy dogs in relation to the fecal microbiota

AC Ericsson, AR Personett, ME Grobman, H Rindt… - PloS one, 2016 - journals.plos.org
The upper and lower airways of healthy humans are reported to harbor stable and
consistent bacterial populations, and the composition of these communities is altered in …

Pangenomic comparison of globally distributed Poribacteria associated with sponge hosts and marine particles

S Podell, JM Blanton, A Neu, V Agarwal… - The ISME …, 2019 - academic.oup.com
Candidatus Poribacteria is a little-known bacterial phylum, previously characterized by
partial genomes from a single sponge host, but never isolated in culture. We have …