Controlled proteolysis underlies a vast diversity of protective and regulatory processes that
are of key importance to cell fate. The unique molecular architecture of the widely conserved …

Background Articular cartilage defects are a veritable therapeutic problem because
therapeutic options are very scarce. Due to the poor self-regeneration capacity of cartilage …

SF3B1 is the most commonly mutated RNA splicing factor in cancer,,–, but the mechanisms
by which SF3B1 mutations promote malignancy are poorly understood. Here we integrated …

Cells precisely monitor the concentration and functionality of each protein for optimal
performance. Protein quality control involves molecular chaperones, folding catalysts, and …

The HtrA family refers to a group of related oligomeric serine proteases that combine a
trypsin-like protease domain with at least one PDZ interaction domain. Mammals encode …

HtrA1, a member of the mammalian HtrA serine protease family, has a highly conserved
protease domain followed by a PDZ domain. Because HtrA1 is a secretory protein and has …

Histone deacetylases (HDACs) catalyze the removal of acetyl groups from core histones.
Because of their capacity to induce local condensation of chromatin, HDACs are generally …

Human HtrA1 belongs to a widely conserved family of serine proteases involved in various
aspects of protein quality control and cell fate. Although HtrA1 has been implicated in the …

Gram-negative bacteria respond to misfolded proteins in the cell envelope with the σE-
driven expression of periplasmic proteases/chaperones. Activation of σE is controlled by a …

Age-related macular degeneration (AMD) is the leading cause of severe irreversible central
vision loss in individuals over 65 years old. Genome-wide association studies (GWASs) …