A comprehensive review of advanced drug delivery systems for the treatment of rheumatoid arthritis
Q Shen, Y Du - International Journal of Pharmaceutics, 2023 - Elsevier
Rheumatoid arthritis (RA), a chronic autoimmune disease, is characterized by articular pain
and swelling, synovial hyperplasia, and cartilage and bone destruction. Conventional …
and swelling, synovial hyperplasia, and cartilage and bone destruction. Conventional …
Non-invasive management of rheumatoid arthritis using hollow microneedles as a tool for transdermal delivery of teriflunomide loaded solid lipid nanoparticles
H Abd-El-Azim, H Abbas, NS El Sayed… - International Journal of …, 2023 - Elsevier
Conventional RA treatments required prolonged therapy courses that have been
accompanied with numerous side effects impairing the patient's quality of life. Therefore …
accompanied with numerous side effects impairing the patient's quality of life. Therefore …
Lipidic cubic-phase leflunomide nanoparticles (cubosomes) as a potential tool for breast cancer management
M Zewail, PM E. Gaafar, MM Ali, H Abbas - Drug Delivery, 2022 - Taylor & Francis
Despite the fact of availability of several treatments for breast cancer, most of them fail to
attain the desired therapeutic response due to their poor bioavailability, high doses, non …
attain the desired therapeutic response due to their poor bioavailability, high doses, non …
[HTML][HTML] The Role of Polymeric Biomaterials in the Treatment of Articular Osteoarthritis
C Velasco-Salgado, GM Pontes-Quero… - Pharmaceutics, 2022 - mdpi.com
Osteoarthritis is a high-prevalence joint disease characterized by the degradation of
cartilage, subchondral bone thickening, and synovitis. Due to the inability of cartilage to self …
cartilage, subchondral bone thickening, and synovitis. Due to the inability of cartilage to self …
Synergistic and receptor-mediated targeting of arthritic joints via intra-articular injectable smart hydrogels containing leflunomide-loaded lipid nanocarriers
Intra-articular drug delivery represents a tempting strategy for local treatment of rheumatoid
arthritis. Targeting drugs to inflamed joints bypasses systemic-related side effects. Albeit …
arthritis. Targeting drugs to inflamed joints bypasses systemic-related side effects. Albeit …
Hyaluronic acid coated teriflunomide (A771726) loaded lipid carriers for the oral management of rheumatoid arthritis
M Zewail, NM El-Deeb, MR Mousa, H Abbas - International Journal of …, 2022 - Elsevier
Systemic rheumatoid arthritis treatment has been associated with numerous side effects. We
attempted to formulate hyaluronic acid (HA)-coated teriflunomide (TER)-loaded …
attempted to formulate hyaluronic acid (HA)-coated teriflunomide (TER)-loaded …
Coated nanostructured lipid carriers targeting the joints–An effective and safe approach for the oral management of rheumatoid arthritis
Oral treatment of rheumatoid arthritis (RA) with the immunomodulator, leflunomide (LEF), is
associated with systemic side effects namely immunosuppression and hepatotoxicity …
associated with systemic side effects namely immunosuppression and hepatotoxicity …
[HTML][HTML] Development and evaluation of novel leflunomide SPION bioemulsomes for the intra-articular treatment of arthritis
Systemic treatments for rheumatoid arthritis are associated with many side effects. This study
aimed to minimize the side effects associated with the systemic administration of leflunomide …
aimed to minimize the side effects associated with the systemic administration of leflunomide …
Folic acid decorated chitosan-coated solid lipid nanoparticles for the oral treatment of rheumatoid arthritis
M Zewail - Therapeutic Delivery, 2021 - Taylor & Francis
Background: Systemic treatment of rheumatoid arthritis has been accompanied with several
side effects. This study attempts to reduce leflunomide systemic side effects besides …
side effects. This study attempts to reduce leflunomide systemic side effects besides …
[HTML][HTML] Biodegradable polymer-based microfluidic membranes for sustainable point-of-care devices
Microfluidic paper-based analytical devices (µPADs) have gained substantial attention as
portable analytical devices in various (bio) technological fields, for being affordable, user …
portable analytical devices in various (bio) technological fields, for being affordable, user …