A comprehensive review of advanced drug delivery systems for the treatment of rheumatoid arthritis

Q Shen, Y Du - International Journal of Pharmaceutics, 2023 - Elsevier
Rheumatoid arthritis (RA), a chronic autoimmune disease, is characterized by articular pain
and swelling, synovial hyperplasia, and cartilage and bone destruction. Conventional …

Non-invasive management of rheumatoid arthritis using hollow microneedles as a tool for transdermal delivery of teriflunomide loaded solid lipid nanoparticles

H Abd-El-Azim, H Abbas, NS El Sayed… - International Journal of …, 2023 - Elsevier
Conventional RA treatments required prolonged therapy courses that have been
accompanied with numerous side effects impairing the patient's quality of life. Therefore …

Lipidic cubic-phase leflunomide nanoparticles (cubosomes) as a potential tool for breast cancer management

M Zewail, PM E. Gaafar, MM Ali, H Abbas - Drug Delivery, 2022 - Taylor & Francis
Despite the fact of availability of several treatments for breast cancer, most of them fail to
attain the desired therapeutic response due to their poor bioavailability, high doses, non …

[HTML][HTML] The Role of Polymeric Biomaterials in the Treatment of Articular Osteoarthritis

C Velasco-Salgado, GM Pontes-Quero… - Pharmaceutics, 2022 - mdpi.com
Osteoarthritis is a high-prevalence joint disease characterized by the degradation of
cartilage, subchondral bone thickening, and synovitis. Due to the inability of cartilage to self …

Synergistic and receptor-mediated targeting of arthritic joints via intra-articular injectable smart hydrogels containing leflunomide-loaded lipid nanocarriers

M Zewail, N Nafee, MW Helmy, N Boraie - Drug delivery and translational …, 2021 - Springer
Intra-articular drug delivery represents a tempting strategy for local treatment of rheumatoid
arthritis. Targeting drugs to inflamed joints bypasses systemic-related side effects. Albeit …

Hyaluronic acid coated teriflunomide (A771726) loaded lipid carriers for the oral management of rheumatoid arthritis

M Zewail, NM El-Deeb, MR Mousa, H Abbas - International Journal of …, 2022 - Elsevier
Systemic rheumatoid arthritis treatment has been associated with numerous side effects. We
attempted to formulate hyaluronic acid (HA)-coated teriflunomide (TER)-loaded …

Coated nanostructured lipid carriers targeting the joints–An effective and safe approach for the oral management of rheumatoid arthritis

M Zewail, N Nafee, MW Helmy, N Boraie - International Journal of …, 2019 - Elsevier
Oral treatment of rheumatoid arthritis (RA) with the immunomodulator, leflunomide (LEF), is
associated with systemic side effects namely immunosuppression and hepatotoxicity …

[HTML][HTML] Development and evaluation of novel leflunomide SPION bioemulsomes for the intra-articular treatment of arthritis

H Abbas, HA Gad, NS El Sayed, LA Rashed… - Pharmaceutics, 2022 - mdpi.com
Systemic treatments for rheumatoid arthritis are associated with many side effects. This study
aimed to minimize the side effects associated with the systemic administration of leflunomide …

Folic acid decorated chitosan-coated solid lipid nanoparticles for the oral treatment of rheumatoid arthritis

M Zewail - Therapeutic Delivery, 2021 - Taylor & Francis
Background: Systemic treatment of rheumatoid arthritis has been accompanied with several
side effects. This study attempts to reduce leflunomide systemic side effects besides …

[HTML][HTML] Biodegradable polymer-based microfluidic membranes for sustainable point-of-care devices

R Brito-Pereira, C Ribeiro, S Lanceros-Méndez… - Chemical Engineering …, 2022 - Elsevier
Microfluidic paper-based analytical devices (µPADs) have gained substantial attention as
portable analytical devices in various (bio) technological fields, for being affordable, user …