With over thirty different hormones identified as being produced in the gastrointestinal (GI)
tract, the gut has been described as 'the largest endocrine organ in the body'(Ann. Oncol …

Gastrointestinal (GI) vagal afferents convey sensory signals from the GI tract to the brain.
Numerous subtypes of GI vagal afferent have been identified but their individual roles in gut …

The enteroendocrine cell is the cornerstone of gastrointestinal chemosensation. In the
intestine and colon, this cell is stimulated by nutrients, tastants that elicit the perception of …

Background & Aims Gastrointestinal (GI) motility is regulated by serotonin (5-
hydroxytryptamine [5-HT]), which is primarily produced by enterochromaffin (EC) cells in the …

Mechanisms by which gut luminal content regulates secretion and motility are ill understood.
We evaluated whether neuroendocrine enterochromaffin (EC) cells act as luminal sensors …

The intestinal epithelium plays a key role in managing the relationship with the environment,
the internal and external inputs, and their changes. One percent of the gut epithelium is …

This mini‐review addresses the role of the neuroendocrine substance serotonin (5‐
hydroxytryptamine, 5‐HT) in intestinal luminal sensing and secretion. Intestinal sensory …

Enteroendocrine cells (EECs) are sensory cells of the gastrointestinal tract. Most EECs
reside in the mucosal lining of the stomach or intestine and sense food in the gut lumen …

Disorders of gut-brain interaction (DGBIs) are common conditions in community and clinical
practice. As specialized enteroendocrine cells, enterochromaffin (EC) cells produce up to …

Inflammatory bowel disease (IBD) is a chronic recurrent condition whose etiology is
unknown, and it includes ulcerative colitis, Crohn's disease, and microscopic colitis. These …