Malaria in pregnancy: pathogenesis and immunity
Understanding of the biological basis for susceptibility to malaria in pregnancy was recently
advanced by the discovery that erythrocytes infected with Plasmodium falciparum …
advanced by the discovery that erythrocytes infected with Plasmodium falciparum …
[HTML][HTML] Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies
P Khunrae, M Dahlbäck, MA Nielsen… - Journal of molecular …, 2010 - Elsevier
Plasmodium falciparum malaria remains one of the world's leading causes of human
suffering and poverty. Each year, the disease takes 1–3 million lives, mainly in sub-Saharan …
suffering and poverty. Each year, the disease takes 1–3 million lives, mainly in sub-Saharan …
[HTML][HTML] Establishment and validation of a plasma oncofetal chondroitin sulfated proteoglycan for pan-cancer detection
PF Zhang, ZY Wu, WB Zhang, YQ He, K Chen… - Nature …, 2023 - nature.com
Various biomarkers targeting cell-free DNA (cfDNA) and circulating proteins have been
tested for pan-cancer detection. Oncofetal chondroitin sulfate (ofCS), which distinctively …
tested for pan-cancer detection. Oncofetal chondroitin sulfate (ofCS), which distinctively …
Pregnancy-associated malaria: parasite binding, natural immunity and vaccine development
Humans living in areas of high malaria transmission gradually acquire, during the early
years of life, protective clinical immunity to Plasmodium falciparum, limiting serious …
years of life, protective clinical immunity to Plasmodium falciparum, limiting serious …
[HTML][HTML] Surface Co-Expression of Two Different PfEMP1 Antigens on Single Plasmodium falciparum-Infected Erythrocytes Facilitates Binding to ICAM1 and PECAM1
L Joergensen, DC Bengtsson, A Bengtsson… - PLoS …, 2010 - journals.plos.org
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens play a
major role in cytoadhesion of infected erythrocytes (IE), antigenic variation, and immunity to …
major role in cytoadhesion of infected erythrocytes (IE), antigenic variation, and immunity to …
[HTML][HTML] Var2CSA minimal CSA binding region is located within the N-terminal region
A Srivastava, S Gangnard, S Dechavanne, F Amirat… - PloS one, 2011 - journals.plos.org
Var2CSA, a key molecule linked with pregnancy-associated malaria (PAM), causes
sequestration of Plasmodium falciparum infected erythrocytes (PEs) in the placenta by …
sequestration of Plasmodium falciparum infected erythrocytes (PEs) in the placenta by …
Human pregnancy‐associated malaria‐specific B cells target polymorphic, conformational epitopes in VAR2CSA: This article became available OnlineOpen after it …
L Barfod, NL Bernasconi, M Dahlbäck… - Molecular …, 2007 - Wiley Online Library
Pregnancy‐associated malaria (PAM) is caused by Plasmodium falciparum‐infected
erythrocytes (IEs) that bind to chondroitin sulphate A (CSA) in the placenta by PAM …
erythrocytes (IEs) that bind to chondroitin sulphate A (CSA) in the placenta by PAM …
Induction of Adhesion-Inhibitory Antibodies against Placental Plasmodium falciparum Parasites by Using Single Domains of VAR2CSA
MA Nielsen, VV Pinto, M Resende… - Infection and …, 2009 - Am Soc Microbiol
In areas of endemicity pregnancy-associated malaria is an important cause of maternal
anemia, stillbirth, and delivery of low-birth-weight children. The syndrome is precipitated by …
anemia, stillbirth, and delivery of low-birth-weight children. The syndrome is precipitated by …
[HTML][HTML] Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
M Cyrklaff, S Srismith, B Nyboer, K Burda… - Nature …, 2016 - nature.com
Plasmodium falciparum infections can cause severe malaria, but not every infected person
develops life-threatening complications. In particular, carriers of the structural …
develops life-threatening complications. In particular, carriers of the structural …
[HTML][HTML] High avidity antibodies to full-length VAR2CSA correlate with absence of placental malaria
VAR2CSA mediates sequestration of Plasmodium falciparum-infected erythrocytes in the
placenta, increasing the risk of poor pregnancy outcomes. Naturally acquired antibodies …
placenta, increasing the risk of poor pregnancy outcomes. Naturally acquired antibodies …