Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges
Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st
century. It is a well-recognized multifactorial health problem contributes significantly to high …
century. It is a well-recognized multifactorial health problem contributes significantly to high …
[HTML][HTML] A review of the recent development in the synthesis and biological evaluations of pyrazole derivatives
O Ebenezer, M Shapi, JA Tuszynski - Biomedicines, 2022 - mdpi.com
Pyrazoles are five-membered heterocyclic compounds that contain nitrogen. They are an
important class of compounds for drug development; thus, they have attracted much …
important class of compounds for drug development; thus, they have attracted much …
Effects of hydroxylation at C3′ on the B ring and diglycosylation at C3 on the C ring on flavonols inhibition of α-glucosidase activity
The structure–activity relationship and inhibitory mechanism of flavonols on α-glucosidase
were studied by inhibition kinetics, multispectral study, and molecular docking. The flavonols …
were studied by inhibition kinetics, multispectral study, and molecular docking. The flavonols …
Bio-oriented synthesis of novel polyhydroquinoline derivatives as α-glucosidase inhibitor for management of diabetes
Polyhydroquinoline derivatives (1-15) were synthesized through an unsymmetrical Hantzsch
reaction in excellent yields by treating 3, 5-dibromo-4-hydroxybenzaldehyde, dimedone …
reaction in excellent yields by treating 3, 5-dibromo-4-hydroxybenzaldehyde, dimedone …
Triazolothiadiazoles and triazolothiadiazines as potent α-glucosidase inhibitors: Mechanistic insights from kinetics studies, molecular docking and dynamics …
Diabetes mellitus has been considered as a serious health problem worldwide due its high
prevalence rate and associated complications. In this context, the current research work …
prevalence rate and associated complications. In this context, the current research work …
Meldrum-Based-1H-1,2,3-Triazoles as Antidiabetic Agents: Synthesis, In Vitro α-Glucosidase Inhibition Activity, Molecular Docking Studies, and In Silico Approach
A series of novel alkyl derivatives (2–5a, b) and 1 H-1, 2, 3-triazole analogues (7a–k) of
Meldrum's acid were synthesized in a highly effective way by using “click” chemistry and …
Meldrum's acid were synthesized in a highly effective way by using “click” chemistry and …
[HTML][HTML] In-vivo anti-diabetic and anti-hyperlipidemic effects of natural metabolites from resin of Commiphora mukul and their in-silico to in-vitro target fishing
Diabetes mellitus is a rapidly spreading global metabolic disorder that has serious social,
health, and economic consequences. Herein, we have evaluated in vivo antidiabetic and …
health, and economic consequences. Herein, we have evaluated in vivo antidiabetic and …
Polyhydroquinoline Derivatives for Diabetic Management: Synthesis, in Vitro and in Silico Approaches
F Talab, Zainab, A Alam, M Ali… - Future Medicinal …, 2023 - Taylor & Francis
Background: Medication used to treat Type 2 diabetes by decreasing the absorption of
carbohydrates in the intestine consists of α-glucosidase inhibitors. Polyhydroquinoline …
carbohydrates in the intestine consists of α-glucosidase inhibitors. Polyhydroquinoline …
Synthesis of new diphenyl urea-clubbed imine analogs and its Implications in diabetic management through in vitro and in silico approaches
Type II diabetes mellitus (T2DM) is a global health issue with high rate of prevalence. The
inhibition of α-glucosidase enzyme has prime importance in the management of T2DM. This …
inhibition of α-glucosidase enzyme has prime importance in the management of T2DM. This …
GC-MS Analysis and Biomedical Therapy of Oil from n-Hexane Fraction of Scutellaria edelbergii Rech. f.: In Vitro, In Vivo, and In Silico Approach
The current study aimed to explore the crude oils obtained from the n-hexane fraction of
Scutellaria edelbergii and further analyzed, for the first time, for their chemical composition …
Scutellaria edelbergii and further analyzed, for the first time, for their chemical composition …