Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

The integrin family of cell adhesion receptors regulates a diverse array of cellular functions
crucial to the initiation, progression and metastasis of solid tumours. The importance of …

Correlative clinical evidence and experimental observations indicate that integrin adhesion
receptors, in particular those of the αV family, are relevant to cancer cell features, including …

Since RGD peptides (R: arginine; G: glycine; D: aspartic acid) have been found to promote
cell adhesion in 1984 (Cell attachment activity of fibronectin can be duplicated by small …

How ligand binding alters integrin conformation in outside-in signaling, and how inside-out
signals alter integrin affinity for ligand, have been mysterious. We address this with electron …

Inhibitors of αvβ3 and αvβ5 integrin have entered clinical trials as antiangiogenic agents for
cancer treatment but generally have been unsuccessful. Here we present in vivo evidence …

Pharmacological agents directed against the integrins αvβ3 and αvβ5 have been reported to
inhibit angiogenesis. However, genetic ablations of the genes encoding these integrins fail …

Integrins are a structurally elaborate family of adhesion molecules that transmit signals bi-
directionally across the plasma membrane by undergoing large-scale structural …

During cell migration, the physical link between the extracellular substrate and the actin
cytoskeleton mediated by receptors of the integrin family is constantly modified. We …

Integrins are cell–substrate adhesion molecules that provide the essential link between the
actin cytoskeleton and the extracellular matrix during cell migration. We have analyzed αVβ3 …