Mitochondria as a cellular hub in infection and inflammation
Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as
dynamic networks where they adapt energy production based on the cell's needs. They are …
dynamic networks where they adapt energy production based on the cell's needs. They are …
Protein carbonylation, cellular dysfunction, and disease progression
Carbonylation of proteins is an irreversible oxidative damage, often leading to a loss of
protein function, which is considered a widespread indicator of severe oxidative damage …
protein function, which is considered a widespread indicator of severe oxidative damage …
Mass spectrometry–based proteomics analysis of human substantia nigra from Parkinson's disease patients identifies multiple pathways potentially involved in the …
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder
characterized by the loss of dopaminergic neurons in the substantia nigra (SN) of the brain …
characterized by the loss of dopaminergic neurons in the substantia nigra (SN) of the brain …
Protein carbonylation and metal-catalyzed protein oxidation in a cellular perspective
Proteins can become oxidatively modified in many different ways, either by direct oxidation
of amino acid side chains and protein backbone or indirectly by conjugation with oxidation …
of amino acid side chains and protein backbone or indirectly by conjugation with oxidation …
Mitochondrial dysfunction increases allergic airway inflammation
L Aguilera-Aguirre, A Bacsi… - The Journal of …, 2009 - journals.aai.org
The prevalence of allergies and asthma among the world's population has been steadily
increasing due to environmental factors. It has been described that exposure to ozone …
increasing due to environmental factors. It has been described that exposure to ozone …
Oxidative stress fuels Trypanosoma cruzi infection in mice
Oxidative damage contributes to microbe elimination during macrophage respiratory burst.
Nuclear factor, erythroid-derived 2, like 2 (NRF2) orchestrates antioxidant defenses …
Nuclear factor, erythroid-derived 2, like 2 (NRF2) orchestrates antioxidant defenses …
Redox regulation of mitochondrial ATP synthase: implications for cardiac resynchronization therapy
Rationale: Cardiac resynchronization therapy (CRT) is an effective clinical treatment for
heart failure patients with conduction delay, impaired contraction, and energetics. Our recent …
heart failure patients with conduction delay, impaired contraction, and energetics. Our recent …
Detection and analysis of protein–protein interactions in organellar and prokaryotic proteomes by native gel electrophoresis:(membrane) protein complexes and …
F Krause - Electrophoresis, 2006 - Wiley Online Library
It is an essential and challenging task to unravel protein–protein interactions in their actual
in vivo context. Native gel systems provide a separation platform allowing the analysis of …
in vivo context. Native gel systems provide a separation platform allowing the analysis of …
Dual and opposite roles of reactive oxygen species (ROS) in Chagas disease: beneficial on the pathogen and harmful on the host
Chagas disease is a neglected tropical disease, which affects an estimate of 6‐7 million
people worldwide. Chagas disease is caused by Trypanosoma cruzi, which is a eukaryotic …
people worldwide. Chagas disease is caused by Trypanosoma cruzi, which is a eukaryotic …
Trypanosoma cruzi infection disturbs mitochondrial membrane potential and ROS production rate in cardiomyocytes
S Gupta, V Bhatia, J Wen, Y Wu, MH Huang… - Free Radical Biology and …, 2009 - Elsevier
In this study, we investigated the role of Trypanosoma cruzi invasion and inflammatory
processes in reactive oxygen species (ROS) production in a mouse atrial cardiomyocyte line …
processes in reactive oxygen species (ROS) production in a mouse atrial cardiomyocyte line …