The antibiotic resistome: a guide for the discovery of natural products as antimicrobial agents

C Hobson, AN Chan, GD Wright - Chemical Reviews, 2021 - ACS Publications
The use of life-saving antibiotics has long been plagued by the ability of pathogenic bacteria
to acquire and develop an array of antibiotic resistance mechanisms. The sum of these …

Crossroads of antibiotic resistance and biosynthesis

TA Wencewicz - Journal of molecular biology, 2019 - Elsevier
The biosynthesis of antibiotics and self-protection mechanisms employed by antibiotic
producers are an integral part of the growing antibiotic resistance threat. The origins of …

Tetracycline-inactivating enzymes from environmental, human commensal, and pathogenic bacteria cause broad-spectrum tetracycline resistance

AJ Gasparrini, JL Markley, H Kumar, B Wang… - Communications …, 2020 - nature.com
Tetracycline resistance by antibiotic inactivation was first identified in commensal organisms
but has since been reported in environmental and pathogenic microbes. Here, we identify …

Omadacycline: a novel oral and intravenous aminomethylcycline antibiotic agent

GG Zhanel, J Esquivel, S Zelenitsky, CK Lawrence… - Drugs, 2020 - Springer
Omadacycline is a novel aminomethylcycline antibiotic developed as a once-daily,
intravenous and oral treatment for acute bacterial skin and skin structure infection (ABSSSI) …

Clinical Symptoms and Outcomes of Severe Pneumonia Caused by Chlamydia psittaci in Southwest China

F Yang, J Li, B Qi, L Zou, Z Shi, Y Lei, J Li… - Frontiers in Cellular …, 2022 - frontiersin.org
Here, we aimed to retrospectively analyze the clinical characteristics of 27 patients with
severe pneumonia caused by Chlamydia psittaci between January 2019 and April 2021 in …

Tetracyclines resistance in Mycoplasma and Ureaplasma urogenital isolates derived from human: a systematic review and meta-analysis

X Wen, MS Nobakht, Y Yang, E Kouhsari… - Annals of Clinical …, 2023 - Springer
Abstract Background Urogenital Mycoplasma infections are considered an important public
health problem, owing to the presence of antibiotic resistance or decreased susceptibility …

Circumventing antimicrobial-resistance and preventing its development in novel, bacterial infection-control strategies

T Yu, G Jiang, R Gao, G Chen, Y Ren, J Liu… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Development of new antimicrobials with ever 'better'bacterial killing has long
been considered the appropriate response to the growing threat of antimicrobial-resistant …

Venturicidin A, a membrane-active natural product inhibitor of ATP synthase potentiates aminoglycoside antibiotics

V Yarlagadda, R Medina, GD Wright - Scientific Reports, 2020 - nature.com
Despite the remarkable advances due to the discovery and development of antimicrobials
agents, infectious diseases remain the second leading cause of death worldwide. This fact …

Sequence-structure-function characterization of the emerging tetracycline destructase family of antibiotic resistance enzymes

KS Blake, H Kumar, A Loganathan, EE Williford… - Communications …, 2024 - nature.com
Tetracycline destructases (TDases) are flavin monooxygenases which can confer resistance
to all generations of tetracycline antibiotics. The recent increase in the number and diversity …

Efficient photocatalytic remediation of typical antibiotics in water via Mn3O4 decorated carbon nitride nanotube

Y He, M Gao, Y Zhou, Y Zhou - Chemosphere, 2023 - Elsevier
Antibiotic abuse will seriously affect the ecology and environment. Photocatalytic oxidation
technology based on carbon nitride (gC 3 N 4) has been widely adopted to treat wastewater …