Chronic inflammation is the main feature of many long-term inflammatory diseases such as
autoimmune diseases, metabolic disorders, and cancer. There is a growing number of …

Glycosylation produces a diverse and abundant repertoire of glycans, which are collectively
known as the glycome. Glycans are one of the four fundamental macromolecular …

IgA nephropathy (IgAN) is the most common primary glomerulonephritis, frequently leading
to end-stage renal disease, as there is no disease-specific therapy. IgAN is diagnosed from …

B cell activation factor of the TNF family (BAFF) is a potent B cell survival factor. BAFF
overexpressing transgenic mice (BAFF-Tg mice) exhibit features of autoimmune disease …

Galactose-deficient IgA1 (Gd-IgA1) plays a crucial role in the development of IgA
nephropathy (IgAN). However, the pathogenic mechanisms driving Gd-IgA1 production have …

Background IgA nephropathy (IgAN) is the most common primary glomerular disease
worldwide and is a leading cause of renal failure. The disease mechanisms are not …

Wiskott–Aldrich Syndrome (WAS) is a severe X-linked Primary Immunodeficiency that affects
1–10 out of 1 million male individuals. WAS is caused by mutations in the WAS Protein …

N-linked protein glycosylation is an essential co-and posttranslational protein modification
that occurs in all three domains of life; the assembly of N-glycans follows a complex …

Objective: Recent outcomes enhanced the critical role of glycosylation pattern of
autoantibodies in the pathophysiology of antibody-mediated autoimmune diseases. In this …

Reactive oxygen species (ROS) carry out prime physiological roles as intracellular signaling
agents, yet pathologically high concentrations of ROS cause irreversible damage to …