The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis
The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
Neural and hormonal control of sexual behavior
KJ Jennings, L De Lecea - Endocrinology, 2020 - academic.oup.com
Gonadal hormones contribute to the sexual differentiation of brain and behavior throughout
the lifespan, from initial neural patterning to “activation” of adult circuits. Sexual behavior is …
the lifespan, from initial neural patterning to “activation” of adult circuits. Sexual behavior is …
Cell-type-specific asynchronous modulation of PKA by dopamine in learning
Reinforcement learning models postulate that neurons that release dopamine encode
information about action and action outcome, and provide a teaching signal to striatal spiny …
information about action and action outcome, and provide a teaching signal to striatal spiny …
Hypothalamic dopamine neurons motivate mating through persistent cAMP signalling
Transient neuromodulation can have long-lasting effects on neural circuits and motivational
states,,–. Here we examine the dopaminergic mechanisms that underlie mating drive and its …
states,,–. Here we examine the dopaminergic mechanisms that underlie mating drive and its …
Locomotion activates PKA through dopamine and adenosine in striatal neurons
The canonical model of striatal function predicts that animal locomotion is associated with
the opposing regulation of protein kinase A (PKA) in direct and indirect pathway striatal …
the opposing regulation of protein kinase A (PKA) in direct and indirect pathway striatal …
[HTML][HTML] Htr2a-expressing cells in the central amygdala control the hierarchy between innate and learned fear
T Isosaka, T Matsuo, T Yamaguchi, K Funabiki… - Cell, 2015 - cell.com
Fear is induced by innate and learned mechanisms involving separate pathways. Here, we
used an olfactory-mediated innate-fear versus learned-fear paradigm to investigate how …
used an olfactory-mediated innate-fear versus learned-fear paradigm to investigate how …
An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice
Protein kinases control nearly every facet of cellular function. These key signaling nodes
integrate diverse pathway inputs to regulate complex physiological processes, and aberrant …
integrate diverse pathway inputs to regulate complex physiological processes, and aberrant …
The neural circuits of mating and fighting in male mice
Highlights•Mating and aggression can be divided into appetitive and consummatory
phases.•In rodents, conspecific volatiles activate the main olfactory system to initiate …
phases.•In rodents, conspecific volatiles activate the main olfactory system to initiate …
Loss of plasticity in the D2-accumbens pallidal pathway promotes cocaine seeking
Distinct populations of D1-and D2-dopamine receptor-expressing medium spiny neurons
(D1-/D2-MSNs) comprise the nucleus accumbens, and activity in D1-MSNs promotes …
(D1-/D2-MSNs) comprise the nucleus accumbens, and activity in D1-MSNs promotes …
Ventrolateral striatal medium spiny neurons positively regulate food-incentive, goal-directed behavior independently of D1 and D2 selectivity
A Natsubori, I Tsutsui-Kimura, H Nishida… - Journal of …, 2017 - Soc Neuroscience
The ventral striatum is involved in motivated behavior. Akin to the dorsal striatum, the ventral
striatum contains two parallel pathways: the striatomesencephalic pathway consisting of …
striatum contains two parallel pathways: the striatomesencephalic pathway consisting of …