Computational modeling, formal analysis, and tools for systems biology

E Bartocci, P Lió - PLoS computational biology, 2016 - journals.plos.org
As the amount of biological data in the public domain grows, so does the range of modeling
and analysis techniques employed in systems biology. In recent years, a number of …

Methodologies for the modeling and simulation of biochemical networks, illustrated for signal transduction pathways: A primer

N ElKalaawy, A Wassal - Biosystems, 2015 - Elsevier
Biochemical networks depict the chemical interactions that take place among elements of
living cells. They aim to elucidate how cellular behavior and functional properties of the cell …

Marcie-model checking and reachability analysis done efficiently

M Schwarick, M Heiner, C Rohr - 2011 Eighth International …, 2011 - ieeexplore.ieee.org
MARCIE is a multi-threaded tool for the analysis of Generalized Stochastic Petri Nets. Its
capabilities range from standard properties of qualitative Petri nets to CTL and CSL model …

A comparative study of stochastic analysis techniques

M Heiner, C Rohr, M Schwarick, S Streif - Proceedings of the 8th …, 2010 - dl.acm.org
Stochastic models are becoming increasingly popular in Systems Biology. They are
compulsory, if the stochastic noise is crucial for the behavioural properties to be …

Formal verification confirms the role of p53 protein in cell fate decision mechanism

EA Mahmoud, M Herajy, IE Ziedan, HI Shehata - Theory in Biosciences, 2023 - Springer
The bio-cell cycle is controlled by a complex biochemical network of signaling pathways.
Modeling such challenging networks accurately is imperative for the understanding of their …

Petri net-based approach to modeling and analysis of selected aspects of the molecular regulation of angiogenesis

D Formanowicz, M Radom, P Zawierucha… - PloS one, 2017 - journals.plos.org
The functioning of both normal and pathological tissues depends on an adequate supply of
oxygen through the blood vessels. A process called angiogenesis, in which new endothelial …

Simulative model checking of steady state and time-unbounded temporal operators

C Rohr - Transactions on petri nets and other models of …, 2013 - Springer
When working with large stochastic models simulation remains the only possible analysis
technique. Therefore, simulative model checking is the way to go. While finite time horizon …

Modeling smart grid using generalized stochastic petri net

A Dey, N Chaki, S Sanyal - arXiv preprint arXiv:1108.4139, 2011 - arxiv.org
Building smart grid for power system is a major challenge for safe, automated and energy
efficient usage of electricity. The full implementation of the smart grid will evolve over time …

[PDF][PDF] Simulative analysis of coloured extended stochastic Petri nets

C Rohr - 2017 - pure.mpg.de
Stochastic modelling of biochemical reaction networks is getting more and more popular.
Throughout the past decades typical biological models increased in their size and …

Simplification of a complex signal transduction model using invariants and flow equivalent servers

F Cordero, A Horváth, D Manini, L Napione… - Theoretical Computer …, 2011 - Elsevier
In this paper we consider the modeling of a portion of the signal transduction pathway
involved in the angiogenic process. The detailed model of this process is affected by a high …