Protein factors in pre-mRNA 3′-end processing
CR Mandel, Y Bai, L Tong - Cellular and Molecular Life Sciences, 2008 - Springer
Most eukaryotic mRNA precursors (premRNAs) must undergo extensive processing,
including cleavage and polyadenylation at the 3′-end. Processing at the 3′-end is …
including cleavage and polyadenylation at the 3′-end. Processing at the 3′-end is …
Pre‐mRNA 3′‐end processing complex assembly and function
S Chan, EA Choi, Y Shi - Wiley Interdisciplinary Reviews: RNA, 2011 - Wiley Online Library
The 3′‐ends of almost all eukaryotic mRNAs are formed in a two‐step process, an
endonucleolytic cleavage followed by polyadenylation (the addition of a poly‐adenosine or …
endonucleolytic cleavage followed by polyadenylation (the addition of a poly‐adenosine or …
Molecular architecture of the human pre-mRNA 3′ processing complex
Y Shi, DC Di Giammartino, D Taylor, A Sarkeshik… - Molecular cell, 2009 - cell.com
Pre-mRNA 3′ end formation is an essential step in eukaryotic gene expression. Over half of
human genes produce alternatively polyadenylated mRNAs, suggesting that regulated …
human genes produce alternatively polyadenylated mRNAs, suggesting that regulated …
Structural insights into the human pre-mRNA 3′-end processing machinery
Summary The mammalian pre-mRNA 3′-end-processing machinery consists of cleavage
and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), and other …
and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), and other …
Recent molecular insights into canonical pre-mRNA 3'-end processing
The majority of eukaryotic messenger RNA precursors (pre-mRNAs) undergo cleavage and
polyadenylation at their 3′ end. This canonical 3′-end processing depends on sequence …
polyadenylation at their 3′ end. This canonical 3′-end processing depends on sequence …
RNA binding and RNA remodeling activities of the half-a-tetratricopeptide (HAT) protein HCF107 underlie its effects on gene expression
K Hammani, WB Cook… - Proceedings of the …, 2012 - National Acad Sciences
The half-a-tetratricopeptide repeat (HAT) motif is a helical repeat motif found in proteins that
influence various aspects of RNA metabolism, including rRNA biogenesis, RNA splicing …
influence various aspects of RNA metabolism, including rRNA biogenesis, RNA splicing …
Delineating the structural blueprint of the pre-mRNA 3′-end processing machinery
Processing of mRNA precursors (pre-mRNAs) by polyadenylation is an essential step in
gene expression. Polyadenylation consists of two steps, cleavage and poly (A) synthesis …
gene expression. Polyadenylation consists of two steps, cleavage and poly (A) synthesis …
Detection of alpha-rod protein repeats using a neural network and application to huntingtin
GA Palidwor, S Shcherbinin, MR Huska… - PLoS computational …, 2009 - journals.plos.org
A growing number of solved protein structures display an elongated structural domain,
denoted here as alpha-rod, composed of stacked pairs of anti-parallel alpha-helices. Alpha …
denoted here as alpha-rod, composed of stacked pairs of anti-parallel alpha-helices. Alpha …
RNA-binding proteins in regulation of alternative cleavage and polyadenylation
Almost all eukaryotic pre-mRNAs are processed at the 3′ end by the cleavage and
polyadenylation (C/P) reaction, which preludes termination of transcription and gives rise to …
polyadenylation (C/P) reaction, which preludes termination of transcription and gives rise to …
Mutation of the polyadenylation complex subunit CstF77 reveals that mRNA 3′ end formation and HSP101 levels are critical for a robust heat stress response
Abstract Heat shock protein 101 (HSP101) in plants, and bacterial and yeast orthologs, is
essential for thermotolerance. To investigate thermotolerance mechanisms involving …
essential for thermotolerance. To investigate thermotolerance mechanisms involving …