Although there is no shortage of potential targets for cancer therapeutics, we know of only a
handful of molecules that are differentially expressed in cancer and intersect multiple …

A little over 10 years after its discovery in 1997, the small inhibitor of apoptosis (IAP) protein,
survivin, continues to generate intense interest and keen attention from disparate segments …

Activation of normally silent tissue-specific genes and the resulting cell “identity crisis” are
the unexplored consequences of malignant epigenetic reprogramming. We designed a …

Piwi-interacting RNAs (piRNAs), new non-coding small RNAs, are association with
chromatin organization, messenger RNA stability and genome structure. However, the roles …

Piwi proteins and their interaction with piRNAs have rapidly emerged as important
contributors to gene regulation, indicating their crucial function in germline and stem cell …

The PIWI protein acts as a predictive marker for human gastric cancer - PMC Back to Top Skip to
main content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main Content …

Introduction Basal-type, or triple-negative, breast cancer (lacking estrogen receptor,
progesterone receptor, and human epidermal growth factor receptor-2 expression) is a high …

Purpose: The aim of this study was to evaluate the clinical relevance of the presence of
disseminated tumor cells in peripheral blood (so-called circulating tumor cells) for renal cell …

Despite progress in the management of breast cancer, the molecular underpinnings of
clinically aggressive subtypes of the disease are not well-understood. Here, we show that …

RASSF1C up-regulates important genes involved in lung cancer cell growth, including a
stem cell self-renewal gene, piwil1. In this article, we report the identification of small …