As life expectancy increases, malfunction or loss of tissue caused by injury or disease leads
to reduced quality of life in many patients at significant socioeconomic cost. Even though …

The combined application of molecular, biochemical, histochemical, and ultrastructural
approaches has defined a temporal sequence of gene expression associated with …

The identity of cells that establish the hematopoietic microenvironment (HME) in human
bone marrow (BM), and of clonogenic skeletal progenitors found in BM stroma, has long …

This second edition of the Bone Mechanics Handbook summarizes the current
understanding of bone mechanics with comprehensive coverage of the histology …

In principle, transplantation of mesenchymal progenitor cells would attenuate or possibly
correct genetic disorders of bone, cartilage and muscle, but clinical support for this concept …

Cells from fetal or neonatal skeleton can synthesize bone-like tissue in vitro. In contrast,
formation of bone-like tissue in vitro by cells derived from adult animals has rarely been …

Osteoporosis is a serious complication of systemic glucocorticoid use. However, while
glucocorticoids increase bone resorption in vitro and in vivo, the mechanism (s) of this effect …

This study examines the osteoblastic properties of the established human osteosarcoma cell
line Saos-2. Saos-2 cells inoculated into diffusion chambers, which were implanted ip into …

FGF-23, a novel member of the FGF family, is the product of the gene mutated in autosomal
dominant hypophosphatemic rickets (ADHR). FGF-23 has been proposed as a circulating …

In seven strains of cultured normal human osteoblast-like cells, a mean of 1615 molecules of
tritium-labeled 17β-estradiol per cell nucleus could be bound to specific nuclear sites. The …