Mechanisms and biomarkers of successful allergen-specific immunotherapy

JF López, MB Imam, P Satitsuksanoa, S Lems… - Asia Pacific …, 2022 - journals.lww.com
Allergen-specific immunotherapy (AIT) is considered the only curative treatment for allergic
diseases mediated by immunoglobulin E (IgE). Currently, the route of administration …

C-type lectin receptor mediated modulation of T2 immune responses to allergens

A Angelina, L Martín-Cruz… - Current Allergy and …, 2023 - Springer
Abstract Purpose of Review Allergic diseases represent a major health problem of
increasing prevalence worldwide. In allergy, dendritic cells (DCs) contribute to both the …

Enhancement of β-Glucan Biological Activity Using a Modified Acid-Base Extraction Method from Saccharomyces cerevisiae

E Mahmoud Amer, SH Saber, A Abo Markeb… - Molecules, 2021 - mdpi.com
Beta glucan (β-glucan) has promising bioactive properties. Consequently, the use of β-
glucan as a food additive is favored with the dual-purpose potential of increasing the fiber …

β-glucan nanoparticles alleviate acute asthma by suppressing ferroptosis and DNA damage in mice

BW Ebeed, IA Abdelmawgood, MA Kotb, NA Mahana… - Apoptosis, 2024 - Springer
Asthma is a severe respiratory disease marked by airway inflammation, remodeling, and
oxidative stress. β-Glucan (BG), a polysaccharide constituent of fungal cellular structures …

Treating allergies via skin–recent advances in cutaneous allergen immunotherapy

LD Nesovic, AK Shakya, HS Gill - Advanced drug delivery reviews, 2022 - Elsevier
Subcutaneous allergen immunotherapy has been practiced clinically for decades to treat
airborne allergies. Recently, the cutaneous route, which exploits the immunocompetence of …

Recent advances in epicutaneous immunotherapy and potential applications in food allergy

PL Hervé, V Dioszeghy, K Matthews, KJ Bee… - Frontiers in …, 2023 - frontiersin.org
Given the potent immunological properties of the skin, epicutaneous immunotherapy (EPIT)
emerges as a promising treatment approach for inducing immune tolerance, particularly for …

Carbohydrates in allergy: from disease to novel immunotherapies

BCK Doungstop, SJ Van Vliet, R Van Ree… - Trends in …, 2021 - cell.com
Respiratory allergic disorders are a global public health problem that are responsible for
substantial morbidity and healthcare expenditure. Despite the availability of allergen …

The role of regulatory T cells in epicutaneous immunotherapy for food allergy

G Liu, M Liu, J Wang, Y Mou, H Che - Frontiers in Immunology, 2021 - frontiersin.org
In recent decades, a rapid increase in the prevalence of food allergies has led to extensive
research on novel treatment strategies and their mechanisms. Mouse models have provided …

An epicutaneous therapeutic pollen-allergen extract delivery system in an allergic rhinitis mouse model: based on allergen loading on DC-specific aptamers …

S Pordel, N Haghnavaz, MA Rezaee, SS Shobeiri… - Immunologic …, 2024 - Springer
Abstract Background Gold nanoparticles (GNPs) have previously been suggested as
appropriate carriers for allergen-specific immunotherapy (AIT). In this study, we assessed …

A Novel C-type lectin receptor-targeted α-synuclein-based parkinson vaccine induces potent immune responses and therapeutic efficacy in mice

S Schmidhuber, S Scheiblhofer, R Weiss, M Cserepes… - Vaccines, 2022 - mdpi.com
The progressive accumulation of misfolded α-synuclein (α-syn) in the brain is widely
considered to be causal for the debilitating clinical manifestations of synucleinopathies …