The lysosome: from waste bag to potential therapeutic target

H Appelqvist, P Wäster, K Kågedal… - Journal of molecular …, 2013 - academic.oup.com
Lysosomes are ubiquitous membrane-bound intracellular organelles with an acidic interior.
They are central for degradation and recycling of macromolecules delivered by endocytosis …

Caspases: the proteases of the apoptotic pathway

G Nuñez, MA Benedict, Y Hu, N Inohara - Oncogene, 1998 - nature.com
Apoptosis, a morphologically defined form of physiological cell death, is implemented by a
death machinery whose executionary arm is a family of cysteine proteases called caspases …

Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay

S Aits, J Kricker, B Liu, AM Ellegaard, S Hämälistö… - Autophagy, 2015 - Taylor & Francis
Lysosomal membrane permeabilization (LMP) contributes to tissue involution, degenerative
diseases, and cancer therapy. Its investigation has, however, been hindered by the lack of …

[HTML][HTML] Two CD95 (APO‐1/Fas) signaling pathways

C Scaffidi, S Fulda, A Srinivasan, C Friesen, F Li… - The EMBO …, 1998 - embopress.org
We have identified two cell types, each using almost exclusively one of two different CD95
(APO‐1/Fas) signaling pathways. In type I cells, caspase‐8 was activated within seconds …

Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-β, and Bcl-2

M Høyer-Hansen, L Bastholm, P Szyniarowski… - Molecular cell, 2007 - cell.com
Macroautophagy is an evolutionary conserved lysosomal pathway involved in the turnover
of cellular macromolecules and organelles. In spite of its essential role in tissue …

Lysosomes in cell death

ME Guicciardi, M Leist, GJ Gores - Oncogene, 2004 - nature.com
For many years apoptosis research has focused on caspases and their putative role as sole
executioners of programmed cell death. Accumulating information now suggests that …

The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet

G van Loo, X Saelens, M Van Gurp… - Cell Death & …, 2002 - nature.com
Mitochondria are 'life-essential'organelles for the production of metabolic energy in the form
of ATP. Paradoxically mitochondria also play a key role in controlling the pathways that lead …

Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies

CC Harris - JNCI: Journal of the National Cancer Institute, 1996 - academic.oup.com
The p53 tumor suppressor protein is involved in multiple central cellular processes,
including transcription, DNA repair, genomic stability, senescence, cell cycle control, and …

TNF-induced signaling in apoptosis

PC Rath, BB Aggarwal - Journal of clinical immunology, 1999 - Springer
Out of the almost 17 members of the TNF superfamily, TNF is probably the most potent
inducer of apoptosis. TNF activates both cell-survival and cell-death mechanisms …

The molecular biology of apoptosis.

DL Vaux, A Strasser - … of the National Academy of Sciences, 1996 - National Acad Sciences
All multicellular organisms have mechanisms for killing their own cells, and use
physiological cell death for defence, development, homeostasis, and aging. Apoptosis is a …