The lysosome: from waste bag to potential therapeutic target
H Appelqvist, P Wäster, K Kågedal… - Journal of molecular …, 2013 - academic.oup.com
Lysosomes are ubiquitous membrane-bound intracellular organelles with an acidic interior.
They are central for degradation and recycling of macromolecules delivered by endocytosis …
They are central for degradation and recycling of macromolecules delivered by endocytosis …
Caspases: the proteases of the apoptotic pathway
G Nuñez, MA Benedict, Y Hu, N Inohara - Oncogene, 1998 - nature.com
Apoptosis, a morphologically defined form of physiological cell death, is implemented by a
death machinery whose executionary arm is a family of cysteine proteases called caspases …
death machinery whose executionary arm is a family of cysteine proteases called caspases …
Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay
Lysosomal membrane permeabilization (LMP) contributes to tissue involution, degenerative
diseases, and cancer therapy. Its investigation has, however, been hindered by the lack of …
diseases, and cancer therapy. Its investigation has, however, been hindered by the lack of …
[HTML][HTML] Two CD95 (APO‐1/Fas) signaling pathways
C Scaffidi, S Fulda, A Srinivasan, C Friesen, F Li… - The EMBO …, 1998 - embopress.org
We have identified two cell types, each using almost exclusively one of two different CD95
(APO‐1/Fas) signaling pathways. In type I cells, caspase‐8 was activated within seconds …
(APO‐1/Fas) signaling pathways. In type I cells, caspase‐8 was activated within seconds …
Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-β, and Bcl-2
M Høyer-Hansen, L Bastholm, P Szyniarowski… - Molecular cell, 2007 - cell.com
Macroautophagy is an evolutionary conserved lysosomal pathway involved in the turnover
of cellular macromolecules and organelles. In spite of its essential role in tissue …
of cellular macromolecules and organelles. In spite of its essential role in tissue …
The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet
Mitochondria are 'life-essential'organelles for the production of metabolic energy in the form
of ATP. Paradoxically mitochondria also play a key role in controlling the pathways that lead …
of ATP. Paradoxically mitochondria also play a key role in controlling the pathways that lead …
Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies
CC Harris - JNCI: Journal of the National Cancer Institute, 1996 - academic.oup.com
The p53 tumor suppressor protein is involved in multiple central cellular processes,
including transcription, DNA repair, genomic stability, senescence, cell cycle control, and …
including transcription, DNA repair, genomic stability, senescence, cell cycle control, and …
TNF-induced signaling in apoptosis
PC Rath, BB Aggarwal - Journal of clinical immunology, 1999 - Springer
Out of the almost 17 members of the TNF superfamily, TNF is probably the most potent
inducer of apoptosis. TNF activates both cell-survival and cell-death mechanisms …
inducer of apoptosis. TNF activates both cell-survival and cell-death mechanisms …
The molecular biology of apoptosis.
DL Vaux, A Strasser - … of the National Academy of Sciences, 1996 - National Acad Sciences
All multicellular organisms have mechanisms for killing their own cells, and use
physiological cell death for defence, development, homeostasis, and aging. Apoptosis is a …
physiological cell death for defence, development, homeostasis, and aging. Apoptosis is a …