Natural biomolecular systems have evolved to form a rich variety of supramolecular
materials and machinery fundamental to cellular function. The assembly of these structures …

Hydrogels can offer cells an extracellular matrix-like growth environment which traditional
culture methods cannot provide. Hydrogels therefore have great value in tissue engineering …

Hydrogels are polymeric networks, capable of absorbing large amounts of water and
biological fluids. They are insoluble due to the presence of chemical or physical cross-links …

Multidrug resistance to chemotherapeutic drugs is one of the major causes for the failure of
cancer treatment. Therefore, there is an urgent need to develop anticancer agents that can …

Background: K-Ras4B modulates downstream signaling at different lipid microdomains.
Results: K-Ras4B farnesyl group spontaneously inserts into the disordered lipid …

Multifunctional nanomedicines with active targeting and stimuli-responsive drug release
function utilizing pathophysiological features of the disease are regarded as an effective …

Liposomes are lipid vesicles made of one or multiple lipid bilayers surrounding an internal
aqueous core. They are broadly employed as models to study membrane structure and …

Lipid membranes are involved in regulating biochemical and biological processes and in
modulating the selective permeability of cells, organelles, and vesicles. Membrane …

Is nucleotide exchange sufficient to activate K-Ras4B? To signal, oncogenic rat sarcoma
(Ras) anchors in the membrane and recruits effectors by exposing its effector lobe. With the …

Aggregation of disordered amyloidogenic peptides into oligomers is the causative agent of
amyloid-related diseases. In solution, disordered protein states are characterized by …