Astrocytes are abundant cells in the brain that regulate multiple aspects of neural tissue
homeostasis by providing structural and metabolic support to neurons, maintaining synaptic …

Insulin and insulin-like growth factor 1 (IGF1) signalling play a central role in the
development and maintenance of neurons in the brain, and in humans neurodevelopmental …

Neurodegenerative disorders, including chemotherapy-induced cognitive impairment, are
associated with neuronal mitochondrial dysfunction. Cisplatin, a commonly used …

Using a novel rat model of Down syndrome (DS), the functional role of the cystathionine-β-
synthase (CBS)/hydrogen sulfide (H 2 S) pathway was investigated on the pathogenesis of …

Cell transplantation is an attractive treatment strategy for a variety of brain disorders, as it
promises to replenish lost functions and rejuvenate the brain. In particular, transplantation of …

Pre-clinical studies of fragile X syndrome (FXS) have focused on neurons, with the role of
glia remaining largely underexplored. We examined the astrocytic regulation of aberrant …

Astrocytes are diverse brain cells that form large networks communicating via gap junctions
and chemical transmitters. Despite recent advances, the functions of astrocytic networks in …

Evidence that glial cells influence behavior has been gaining a steady foothold in scientific
literature. Out of the five main subtypes of glial cells in the brain, astrocytes and microglia …

Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and their
differentiation into neural lineages is a revolutionary experimental system for studying …

Down Syndrome (DS) is the most common genetic cause of intellectual disability in which
delays and impairments in brain development and function lead to neurological and …