Cancer across the tree of life: cooperation and cheating in multicellularity

CA Aktipis, AM Boddy, G Jansen… - … of the Royal …, 2015 - royalsocietypublishing.org
Multicellularity is characterized by cooperation among cells for the development,
maintenance and reproduction of the multicellular organism. Cancer can be viewed as …

Bacterial solutions to multicellularity: a tale of biofilms, filaments and fruiting bodies

D Claessen, DE Rozen, OP Kuipers… - Nature Reviews …, 2014 - nature.com
Although bacteria frequently live as unicellular organisms, many spend at least part of their
lives in complex communities, and some have adopted truly multicellular lifestyles and have …

Metabolic resource allocation in individual microbes determines ecosystem interactions and spatial dynamics

WR Harcombe, WJ Riehl, I Dukovski, BR Granger… - Cell reports, 2014 - cell.com
The interspecies exchange of metabolites plays a key role in the spatiotemporal dynamics of
microbial communities. This raises the question of whether ecosystem-level behavior of …

Experimental evolution of multicellularity

WC Ratcliff, RF Denison, M Borrello… - Proceedings of the …, 2012 - National Acad Sciences
Multicellularity was one of the most significant innovations in the history of life, but its initial
evolution remains poorly understood. Using experimental evolution, we show that key steps …

The multicellular nature of filamentous heterocyst-forming cyanobacteria

A Herrero, J Stavans, E Flores - FEMS microbiology reviews, 2016 - academic.oup.com
Cyanobacteria carry out oxygenic photosynthesis, play a key role in the cycling of carbon
and nitrogen in the biosphere, and have had a large impact on the evolution of life and the …

The evolution of multicellularity: a minor major transition?

RK Grosberg, RR Strathmann - Annu. Rev. Ecol. Evol. Syst., 2007 - annualreviews.org
Benefits of increased size and functional specialization of cells have repeatedly promoted
the evolution of multicellular organisms from unicellular ancestors. Many requirements for …

The multiple origins of complex multicellularity

AH Knoll - Annual Review of Earth and Planetary Sciences, 2011 - annualreviews.org
Simple multicellularity has evolved numerous times within the Eukarya, but complex
multicellular organisms belong to only six clades: animals, embryophytic land plants …

Evolution of cooperation and conflict in experimental bacterial populations

PB Rainey, K Rainey - Nature, 2003 - nature.com
A fundamental problem in biology is the evolutionary transition from single cells to
multicellular life forms,,. During this transition the unit of selection shifts from individual cells …

Why is metabolic labour divided in nitrification?

E Costa, J Pérez, JU Kreft - Trends in microbiology, 2006 - cell.com
Winogradsky discovered in 1890 that nitrification is carried out in two consecutive steps by
two distinct groups of bacteria: ammonia-oxidizing bacteria and nitrite-oxidizing bacteria. An …

Emergence of spatial structure in cell groups and the evolution of cooperation

CD Nadell, KR Foster, JB Xavier - PLoS computational biology, 2010 - journals.plos.org
On its own, a single cell cannot exert more than a microscopic influence on its immediate
surroundings. However, via strength in numbers and the expression of cooperative …