Hypoxia is a non-physiological level of oxygen tension, a phenomenon common in a
majority of malignant tumors. Tumor-hypoxia leads to advanced but dysfunctional …

Heart failure (HF) is a major health-care problem and the prognosis of affected patients is
poor. HF often coexists with a number of comorbidities of which declining renal function is of …

Acute kidney injury (AKI) is a major kidney disease characterized by an abrupt loss of renal
function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI …

Diabetic kidney disease is the most common cause of end-stage kidney disease and poses
a major global health problem. Finding new, safe, and effective strategies to halt this disease …

Abstract Epithelial-mesenchymal transition (EMT), a process by which differentiated
epithelial cells undergo a phenotypic conversion that gives rise to the matrix-producing …

Remarkable phenotype plasticity of epithelial cells underlies morphogenesis, epithelial
repair and tumor invasiveness. Detailed understanding of the contextual cues and molecular …

Recent studies emphasize the role of chronic hypoxia in the tubulointerstitium as a final
common pathway to end-stage renal failure. When advanced, tubulointerstitial damage is …

Epithelial-mesenchymal transition (EMT), a process whereby fully differentiated epithelial
cells undergo transition to a mesenchymal phenotype giving rise to fibroblasts and …

Renal fibrosis is the common pathological hallmark of progressive chronic kidney disease
(CKD) with diverse aetiologies. Recent researches have highlighted the critical role of …

Recent clinical and animal studies have shown that acute kidney injury (AKI), even if
followed by complete recovery of renal function, can eventually result in chronic kidney …