Estrogens and androgens in skeletal physiology and pathophysiology
M Almeida, MR Laurent, V Dubois… - Physiological …, 2017 - journals.physiology.org
Estrogens and androgens influence the growth and maintenance of the mammalian
skeleton and are responsible for its sexual dimorphism. Estrogen deficiency at menopause …
skeleton and are responsible for its sexual dimorphism. Estrogen deficiency at menopause …
Osteoimmunology: the conceptual framework unifying the immune and skeletal systems
K Okamoto, T Nakashima, M Shinohara… - Physiological …, 2017 - journals.physiology.org
The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …
Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics
JY Li, B Chassaing, AM Tyagi… - The Journal of …, 2016 - Am Soc Clin Investig
A eubiotic microbiota influences many physiological processes in the metazoan host,
including development and intestinal homeostasis. Here, we have shown that the intestinal …
including development and intestinal homeostasis. Here, we have shown that the intestinal …
The role of estrogen and androgen receptors in bone health and disease
Mouse models with cell-specific deletion of the estrogen receptor (ER) α, the androgen
receptor (AR) or the receptor activator of nuclear factor κB ligand (RANKL), as well as …
receptor (AR) or the receptor activator of nuclear factor κB ligand (RANKL), as well as …
The gut microbiota regulates bone mass in mice
K Sjögren, C Engdahl, P Henning… - Journal of bone and …, 2012 - academic.oup.com
The gut microbiota modulates host metabolism and development of immune status. Here we
show that the gut microbiota is also a major regulator of bone mass in mice. Germ‐free (GF) …
show that the gut microbiota is also a major regulator of bone mass in mice. Germ‐free (GF) …
Probiotic L. reuteri Treatment Prevents Bone Loss in a Menopausal Ovariectomized Mouse Model
RA Britton, R Irwin, D Quach, L Schaefer… - Journal of cellular …, 2014 - Wiley Online Library
Estrogen deficiency is a major risk factor for osteoporosis that is associated with bone
inflammation and resorption. Half of women over the age of 50 will experience an …
inflammation and resorption. Half of women over the age of 50 will experience an …
Mesenchymal stem cell–based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α
Stem cell–based regenerative medicine is a promising approach in tissue reconstruction.
Here we show that proinflammatory T cells inhibit the ability of exogenously added bone …
Here we show that proinflammatory T cells inhibit the ability of exogenously added bone …
[HTML][HTML] Estrogen regulates bone turnover by targeting RANKL expression in bone lining cells
C Streicher, A Heyny, O Andrukhova, B Haigl… - Scientific reports, 2017 - nature.com
Estrogen is critical for skeletal homeostasis and regulates bone remodeling, in part, by
modulating the expression of receptor activator of NF-κB ligand (RANKL), an essential …
modulating the expression of receptor activator of NF-κB ligand (RANKL), an essential …
Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis
Z Lyu, Y Hu, Y Guo, D Liu - Bone research, 2023 - nature.com
The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being
of the host. Recent studies have demonstrated that the GM may significantly influence bone …
of the host. Recent studies have demonstrated that the GM may significantly influence bone …
Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells
M Yu, S Pal, CW Paterson, JY Li… - The Journal of …, 2021 - Am Soc Clin Investig
Estrogen deficiency causes a gut microbiome–dependent expansion of BM Th17 cells and
TNF-α–producing T cells. The resulting increased BM levels of IL-17a (IL-17) and TNF …
TNF-α–producing T cells. The resulting increased BM levels of IL-17a (IL-17) and TNF …