[HTML][HTML] Ciliopathies and the kidney: a review
DJ McConnachie, JL Stow, AJ Mallett - American Journal of Kidney …, 2021 - Elsevier
Primary cilia are specialized sensory organelles that protrude from the apical surface of most
cell types. Over the past two decades, they have been found to play important roles in tissue …
cell types. Over the past two decades, they have been found to play important roles in tissue …
The genetic architecture of morphological abnormalities of the sperm tail
A Touré, G Martinez, ZE Kherraf, C Cazin, J Beurois… - Human Genetics, 2021 - Springer
Spermatozoa contain highly specialized structural features reflecting unique functions
required for fertilization. Among them, the flagellum is a sperm-specific organelle required to …
required for fertilization. Among them, the flagellum is a sperm-specific organelle required to …
Mapping of neuronal and glial primary cilia contactome and connectome in the human cerebral cortex
JY Wu, SJ Cho, K Descant, PH Li, A Shapson-Coe… - Neuron, 2024 - cell.com
Primary cilia act as antenna receivers of environmental signals and enable effective
neuronal or glial responses. Disruption of their function is associated with circuit disorders …
neuronal or glial responses. Disruption of their function is associated with circuit disorders …
Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium
KC Goldfarbmuren, ND Jackson, SP Sajuthi… - Nature …, 2020 - nature.com
Cigarette smoke first interacts with the lung through the cellularly diverse airway epithelium
and goes on to drive development of most chronic lung diseases. Here, through single cell …
and goes on to drive development of most chronic lung diseases. Here, through single cell …
A change of heart: new roles for cilia in cardiac development and disease
L Djenoune, K Berg, M Brueckner… - Nature Reviews Cardiology, 2022 - nature.com
Although cardiac abnormalities have been observed in a growing class of human disorders
caused by defective primary cilia, the function of cilia in the heart remains an underexplored …
caused by defective primary cilia, the function of cilia in the heart remains an underexplored …
Composition, organization and mechanisms of the transition zone, a gate for the cilium
The cilium evolved to provide the ancestral eukaryote with the ability to move and sense its
environment. Acquiring these functions required the compartmentalization of a dynein …
environment. Acquiring these functions required the compartmentalization of a dynein …
[HTML][HTML] Mitochondrial dysfunction compromises ciliary homeostasis in astrocytes
O Ignatenko, S Malinen, S Rybas… - The Journal of cell …, 2023 - ncbi.nlm.nih.gov
Astrocytes, often considered as secondary responders to neurodegeneration, are emerging
as primary drivers of brain disease. Here we show that mitochondrial DNA depletion in …
as primary drivers of brain disease. Here we show that mitochondrial DNA depletion in …
A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans
J Dobbelaere, TY Su, B Erdi, A Schleiffer… - The EMBO …, 2023 - embopress.org
Cilia are cellular projections that perform sensory and motile functions in eukaryotic cells. A
defining feature of cilia is that they are evolutionarily ancient, yet not universally conserved …
defining feature of cilia is that they are evolutionarily ancient, yet not universally conserved …
Islet primary cilia motility controls insulin secretion
Primary cilia are specialized cell-surface organelles that mediate sensory perception and, in
contrast to motile cilia and flagella, are thought to lack motility function. Here, we show that …
contrast to motile cilia and flagella, are thought to lack motility function. Here, we show that …
Hypoxia inducible factors regulate infectious SARS-CoV-2, epithelial damage and respiratory symptoms in a hamster COVID-19 model
PAC Wing, M Prange-Barczynska, A Cross… - PLoS …, 2022 - journals.plos.org
Understanding the host pathways that define susceptibility to Severe-acute-respiratory-
syndrome-coronavirus-2 (SARS-CoV-2) infection and disease are essential for the design of …
syndrome-coronavirus-2 (SARS-CoV-2) infection and disease are essential for the design of …