Escherichia coli (E. coli) is a gram-negative bacillus and resident of the normal intestinal
microbiota. However, some E. coli strains can cause diseases in humans, other mammals …

The ubiquitin-proteasome system (UPS) and autophagy are the two major intracellular
protein quality control (PQC) pathways that are responsible for cellular proteostasis …

Selective ubiquitin-dependent autophagy plays a pivotal role in the elimination of protein
aggregates, assemblies, or organelles and counteracts the cytotoxicity of proteins linked to …

Rac1 small GTPase controls essential aspects of cell biology and is a direct target of
numerous bacterial virulence factors. The CNF1 toxin of pathogenic Escherichia coli …

Tuberculosis, one of the leading causes of death worldwide, stimulates inflammatory
responses with beneficial and pathologic consequences. The regulation and nature of an …

The ability of bacterial pathogens to invade host cells can have profound effects on the
establishment, persistence, and propagation of infections. By entering host cells and …

Colorectal cancer (CRC) patients are frequently colonized by colibactin-producing
Escherichia coli (CoPEC)(> 40%), which enhances tumorigenesis in mouse models of CRC …

Urinary tract infections (UTIs) are some of the most common bacterial infections worldwide
and are a source of substantial morbidity among otherwise healthy women. UTIs can be …

The Toll-interacting protein (Tollip) is a critical regulator of Toll-like receptor (TLR)-mediated
innate immune responses. Tollip modulates TLR signaling and membrane trafficking …

Simulated microgravity (SMG) was reported to affect tumor cell proliferation and metastasis.
However, the underlying mechanism is elusive. In this study, we demonstrate that clinostat …