Background: Ki67 is an immunohistochemical proliferation marker in many types of cancer
and has been widely studied among breast cancer patients mostly through retrospective …

Progesterone is a sexual steroid hormone that has a critical role in reproductive processes
in males and females of several species, including humans. Furthermore, progesterone has …

Cancer is one of the most common causes of death worldwide, and its development is a
result of the complex interaction of genetic factors, environmental cues, and aging. Hormone …

Steroid hormones bind receptors in the cell nucleus and in the cell membrane. The most
widely studied class of steroid hormone receptors are the nuclear receptors, named for their …

Much emphasis is placed on estrogen (E2) and estrogen receptor (ER) signaling as most
research is focused on understanding E2 and ER's ability to enhance proliferative signals in …

Objective: Triple-negative breast cancer (TNBC) constitutes∼ 15% of all diagnosed invasive
breast cancer cases with limited options for treatment since immunotherapies that target ER …

Breast cancer is one of the major reason for death of women worldwide. As per the
International Agency for Research on Cancer (IARC) statistics, the number of cases of breast …

Endometriosis is one of the most frequent gynecological diseases in reproductive age
women, but its etiology is not completely understood. Endometriosis is characterized by …

Breast cancer is the most diagnosed cancer worldwide and remains the second leading
cause of cancer death. While breast cancer mortality has steadily declined over the past …

Progesterone plays an important role in mammary epithelial cell proliferation and
differentiation. Evidence from experimental and clinical studies indicates that progesterone …