The process of mismatch repair was first postulated to explain the results of experiments on
genetic recombination and bacterial mutagenesis. Mismatch repair has long been known to …

Muir-Torre syndrome is an autosomal-dominant skin condition of genetic origin,
characterised by tumours of the sebaceous gland or keratoacanthoma that are associated …

The autosomal dominant syndrome of Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
is due to germline DNA mismatch repair gene mutations in most cases. However, the …

Background Germ-line mutations in DNA mismatch-repair genes (MSH2, MLH1, PMS1,
PMS2, and MSH6) cause susceptibility to hereditary nonpolyposis colorectal cancer. We …

BACKGROUND Microsatellite instability (MIN) has been identified in a wide variety of
human tumors, both familial and sporadic. In this study the authors attempted to correlate …

Hereditary nonpolyposis colorectal cancer (HNPCC) is inherited as a dominant disorder
caused by germline defects in one of at least four mismatch repair (MMR) genes. Two of …

The DNA mismatch repair genes MSH2 and MLH1 have been shown to account for a major
share of hereditary non-polyposis colorectal cancer (HNPCC). We searched for germline …

The inactivation of the DNA mismah repair (MMR) system, which is associated with the
predisposition to the hereditary non-polyposis colorectal cancer (HNPCC), has also been …

Immunohistochemistry (IHC) of mismatch repair (MMR) proteins in colorectal tumors
together with microsatellite analysis (MSI) can be helpful in identifying families eligible for …

Hereditary nonpolyposis colorectal cancer (HNPCC) describes the condition of a disparate
group of families that have in common a predisposition to colorectal cancer in the absence …