Dysregulation of the endogenous lipid mediators endocannabinoids and their G-protein-
coupled cannabinoid receptors 1 and 2 (CB1R and CB2R) has been implicated in a variety …

Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

The gasotransmitters are a family of gaseous signaling molecules which are produced
endogenously and act at specific receptors to play imperative roles in physiologic and …

Diabetic nephropathy (DN), a chronic complication of diabetes, is charecterized by
glomerular hypertrophy, proteinuria, decreased glomerular filtration, and renal fibrosis …

The endogenous cannabinoid receptor agonist anandamide is a powerful vasodilator of
isolated vascular preparations,,, but its mechanism of action is unclear. Here we show that …

The mammalian body has a highly developed immune system which guards against
continuous invading protein attacks and aims at preventing, attenuating or repairing the …

The hyperdynamic circulatory syndrome observed in chronic liver diseases is a great
example of research that originated from clinical observations and progressed in the last 50 …

Diabetes mellitus is known to trigger retinopathy, neuropathy and nephropathy. Diabetic
nephropathy, a long-term major microvascular complication of uncontrolled hyperglycemia …

Cannabis (marijuana) is not only a frequently abused drug but also has the potential for the
development of useful agents for the treatment of emesis, anorexia and multiple sclerosis. In …

Non-alcoholic fatty liver disease is the clinical hepatic expression of metabolic syndrome.
The prevalence of non-alcoholic fatty liver disease is around 20–30%, and with a rapid …