Lovastatin production: From molecular basis to industrial process optimization
KCL Mulder, F Mulinari, OL Franco, MSF Soares… - Biotechnology …, 2015 - Elsevier
Lovastatin, composed of secondary metabolites produced by filamentous fungi, is the most
frequently used drug for hypercholesterolemia treatment due to the fact that lovastatin is a …
frequently used drug for hypercholesterolemia treatment due to the fact that lovastatin is a …
Mycotoxin producers in the Aspergillus genus: An update
J Varga, N Baranyi, M Chandrasekaran… - Acta Biologica …, 2015 - 160.114.156.156
Mycotoxins are secondary metabolites of fungi. Species assigned to the Aspergillus genus
produce a wide range of mycotoxins which can contaminate several agricultural products …
produce a wide range of mycotoxins which can contaminate several agricultural products …
Optimization of nutrient parameters for lovastatin production by Monascus purpureus MTCC 369 under submerged fermentation using response surface methodology
Lovastatin, an inhibitor of HMG-CoA reductase, was produced by submerged fermentation
using Monascus purpureus MTCC 369. Five nutritional parameters screened using Plackett …
using Monascus purpureus MTCC 369. Five nutritional parameters screened using Plackett …
Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012–2018)
J Romsdahl, CCC Wang - Medchemcomm, 2019 - pubs.rsc.org
Secondary metabolites (SMs) produced by filamentous fungi possess diverse bioactivities
that make them excellent drug candidates. Whole genome sequencing has revealed that …
that make them excellent drug candidates. Whole genome sequencing has revealed that …
Lovastatin production by an oleaginous fungus, Aspergillus terreus KPR12 using sago processing wastewater (SWW)
N Srinivasan, K Thangavelu, S Uthandi - Microbial Cell Factories, 2022 - Springer
Background Lovastatin is one of the first statins to be extensively used for its cholesterol-
lowering ability. It is commercially produced by fermentation. Species belonging to the …
lowering ability. It is commercially produced by fermentation. Species belonging to the …
Exploitation of Aspergillus terreus for the Production of Natural Statins
The fungus Aspergillus (A.) terreus has dominated the biological production of the
“blockbuster” drugs known as statins. The statins are a class of drugs that inhibit HMG-CoA …
“blockbuster” drugs known as statins. The statins are a class of drugs that inhibit HMG-CoA …
Optimization of Fermentation Parameters for Higher Lovastatin Production in Red Mold Rice through Co-culture of Monascus purpureus and Monascus ruber
Monascus, fermented rice (red mold rice), has been found to reduce the serum total
cholesterol and triglyceride due to presence of lovastatin. Lovastatin acts as an inhibitor of 3 …
cholesterol and triglyceride due to presence of lovastatin. Lovastatin acts as an inhibitor of 3 …
A review on lovastatin and its production
Natural statin like lovastatin which is mainly produced byAspergillus terreus strains is an
inhibitor of HMG-CoA reductase, an enzyme involved in the biosynthetic pathway of …
inhibitor of HMG-CoA reductase, an enzyme involved in the biosynthetic pathway of …
Exploitation of Sugarcane Bagasse and Environmentally Sustainable Production, Purification, Characterization, and Application of Lovastatin by Aspergillus terreus …
AMAA Ramadan, RM Shehata, HH El-Sheikh, F Ameen… - Molecules, 2023 - mdpi.com
Using the internal transcribed spacer (ITS) region for identification, three strains of
Aspergillus terreus were identified and designated AUMC 15760, AUMC 15762, and AUMC …
Aspergillus terreus were identified and designated AUMC 15760, AUMC 15762, and AUMC …
Biotransformation of agricultural wastes into lovastatin and optimization of a fermentation process using response surface methodology (RSM)
Lovastatin is a competitive inhibitor of the enzyme 3-hydroxy-3-methyl-glutaryl-CoA
reductase (HMG-CoA Reductase). The HMG-CoA reductase is responsible for the …
reductase (HMG-CoA Reductase). The HMG-CoA reductase is responsible for the …