Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

Innate immunity within the central nervous system (CNS) is primarily provided by resident
microglia. Microglia are pivotal in immune surveillance and also facilitate the co‐ordinated …

Aging is the leading risk factor for several age-associated diseases such as
neurodegenerative diseases. Understanding the biology of aging mechanisms is essential …

Deciphering the secret of successful aging depends on understanding the patterns and
biological underpinnings of cognitive and behavioral changes throughout adulthood. That …

Acute cognitive impairment (ie, delirium) is common in elderly emergency department
patients and frequently results from infections that are unrelated to the central nervous …

Background Activation of the peripheral innate immune system stimulates the secretion of
CNS cytokines that modulate the behavioral symptoms of sickness. Excessive production of …

In the elderly, systemic infection is associated with an increased frequency of behavioral and
cognitive complications. We have reported that peripheral stimulation of the innate immune …

The adaptive arm of the immune system has been suggested as an important factor in brain
function. However, given the fact that interactions of neurons or glial cells with T lymphocytes …

Alzheimer's disease (AD), the most common cause of dementia among the elderly, may
either represent the far end of a continuum that begins with age-related memory decline or a …

Gene expression microarrays provide a powerful new tool for studying complex processes
such as brain aging. However, inferences from microarray data are often hindered by …