Sepsis affects practically all aspects of endothelial cell (EC) function and is thought to be the
key factor in the progression from sepsis to organ failure. Endothelial functions affected by …

There is overwhelming evidence that sepsis and septic shock are associated with
hyperlactatemia (sepsis-associated hyperlactatemia (SAHL)). SAHL is a strong independent …

Purpose Hand-held vital microscopes (HVMs) were introduced to observe sublingual
microcirculatory alterations at the bedside in different shock states in critically ill patients …

Objectives: Sepsis induces microvascular alterations that may play an important role in the
development of organ dysfunction. However, the relationship of these alterations to systemic …

Development of organ dysfunction is the most important clinical event during sepsis, as it
directly relates to mortality and morbidity. Although the new definition of sepsis captures this …

Multiple experimental and human trials have shown that microcirculatory alterations are
frequent in sepsis. In this review, we discuss the various mechanisms that are potentially …

Microvascular blood flow alterations are frequent in animal models of sepsis and may impair
tissue oxygenation. We hypothesized that alterations of the microcirculation are present in …

The cortical angioarchitecture is a key factor in controlling cerebral blood flow and oxygen
metabolism. Difficulties in imaging the complex microanatomy of the cortex have so far …

Introduction Microvascular alterations may play an important role in the development of
organ failure in critically ill patients and especially in sepsis. Recent advances in technology …

Purpose To discuss the techniques currently available to evaluate the microcirculation in
critically ill patients. In addition, the most clinically relevant microcirculatory alterations will …